115 Six cases of relapsing polychondritis presenting as severe airways disease to a secondary care centre in one year
Bibliographic record
Abstract
Background: Relapsing polychondritis (RP) a multi-system disease characterised by episodes of progressive inflammation and subsequent degeneration of cartilage and connective tissue throughout the body. The incidence of this condition is believed to be less than one in a million in the UK (Hazra et al 2015). We present six cases of RP identified at a local respiratory department during a single year whose symptoms had previously been attributed to either severe asthma or severe chronic obstructive pulmonary disease (COPD). Methods: All patients had presented to the difficult airways clinic at University Hospital Coventry and Warwickshire NHS Trust (UHCW) in Coventry with severe breathlessness, cough and wheeze. RP was diagnosed using the McAdam criteria and disease activity assessed using the Relapsing Polychondritis Disease Activity Index (RPDAI). Tracheobronchomalacia was usually initially suspected on clinical examination particularly the presence of fixed inspiratory or harsh monophonic inspiratory and expiratory wheeze. Diagnosis was confirmed by a combination of lung function testing, inspiratory and expiratory CT and bronchoscopy.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".