SHORT TERM NEONATAL OUTCOMES IN PREGNANCY INDUCED HYPERTENSION
Bibliographic record
Abstract
Abstract BACKGROUND Studies have demonstrated heterogeneity in association of pregnancy-induced hypertension (PIH) and respiratory outcomes or mortality in preterm infants, largely attributed to effect of gestation and antenatal steroids (survival bias). OBJECTIVES To comparatively evaluate mortality and short-term respiratory outcomes in preterm infants < 33 weeks GA born to mothers with and without PIH. DESIGN/METHODS This retrospective cohort study of preterm infants younger than 33 weeks’ gestation born between July 1, 2014 to June 30, 2016 was conducted at a tertiary academic hospital. Infants exposed to PIH (exposure) were matched to infants not exposed to PIH (control) in a 1:2 ratio, based on gestation, sex and antenatal steroid exposure status. The primary outcomes were respiratory index (RI), mortality and bronchopulmonary dysplasia (BPD). RI was defined as area under curve (AUC) for mean airway pressure and fraction inspired oxygen on invasive ventilation during first 72 hours. RESULTS Of 539 infants, 79 (exposure) were matched with 158 infants (control). Infants born to mothers with PIH had lower birth weight, more likely to delivered through caesarean section and less likely to exposed to chorioamnionitis compared to infants born to mothers without PIH. No differences in RI were noted in infants with (median 1854; IQR 186, 13901) or without PIH (median 1359; IQR 210, 11302) (P-value 0.63). On conditional regression analysis, PIH did not predict RI (adjusted risk 1.15; 95% C.I 0.69–1.90; P value 0.594). No association between PIH and death (OR 3.14; 95% C.I 0.76–13.0; P-value 0.11) was identified. PIH was significantly associated with BPD on univariate analysis (odds ratio (OR) 2.29; 95% C.I 1.02–5.17; P-value 0.046), but on regression analysis was not significant (adjusted OR 1.26; 95% C.I 0.38–4.19; P-value 0.7) (Table 1). CONCLUSION PIH was not associated with RI, mortality or BPD in this matched cohort. This contradicts from previous studies which may have been influenced with the survival bias. Further studies with larger samples are needed to confirm our results.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.003 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".