Novel genes and insights in complete asthma remission: A genome‐wide association study on clinical and complete asthma remission
Bibliographic record
Abstract
Summary Background Asthma is a chronic respiratory disease without a cure, although there exists spontaneous remission. Genome‐wide association ( GWA ) studies have pinpointed genes associated with asthma development, but did not investigate asthma remission. Objective We performed a GWA study to develop insights in asthma remission. Methods Clinical remission (ClinR) was defined by the absence of asthma treatment and wheezing in the last year and asthma attacks in the last 3 years and complete remission (ComR) similarly but additionally with normal lung function and absence of bronchial hyperresponsiveness ( BHR ). A GWA study on both ClinR and ComR was performed in 790 asthmatics with initial doctor diagnosis of asthma and BHR and long‐term follow‐up. We assessed replication of the 25 top single nucleotide polymorphisms ( SNP s) in 2 independent cohorts (total n = 456), followed by expression quantitative loci ( eQTL ) analyses of the 4 replicated SNP s in lung tissue and epithelium. Results Of the 790 asthmatics, 178 (23%) had ClinR and 55 ComR (7%) after median follow‐up of 15.5 (range 3.3‐47.8) years. In ClinR, 1 of the 25 SNP s, rs2740102, replicated in a meta‐analysis of the replication cohorts, which was an eQTL for POLI in lung tissue. In ComR, 3 SNP s replicated in a meta‐analysis of the replication cohorts. The top‐hit, rs6581895, almost reached genome‐wide significance ( P ‐value 4.68 × 10 −7 ) and was an eQTL for FRS 2 and CCT in lung tissue. Rs1420101 was a cis‐ eQTL in lung tissue for IL 1 RL 1 and IL 18R1 and a trans‐ eQTL for IL13 . Conclusions and Clinical Relevance By defining a strict remission phenotype, we identified 3 SNP s to be associated with complete asthma remission, where 2 SNP s have plausible biological relevance in FRS 2 , CCT , IL 1 RL 1, IL 18R1 and IL 13 .
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".