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Dabigatran in patients with myocardial injury after non-cardiac surgery (MANAGE): an international, randomised, placebo-controlled trial
P.J. Devereaux, Emmanuelle Duceppe, Gordon Guyatt, Vikas Tandon, Reitze Rodseth, Bruce Biccard, Denis Xavier, Wojciech Szczeklik, Christian S. Meyhoff, Jessica Vincent, Maria Grazia Franzosi, Sadeesh Srinathan, Jason Erb, Patrick Magloire, John Neary, Mangala Rao, Prashant V Rahate, Navneet Kumar Chaudhry, Bongani M. Mayosi, Miriam de Nadal, Pilar Paniagua Iglesias, Otávio Berwanger, Juan Carlos Villar, Fernando Botto, John W. Eikelboom, Daniel I. Sessler, Clive Kearon, Shirley Pettit, Mukul Sharma, Stuart J. Connolly, Shrikant I. Bangdiwala, Rao Ps, Andreas Hoeft, Salim Yusuf, Janice Pogue, Sara Di Diodato, Zora Gasic, Louise Mastrangelo, S. Molnar, Jennifer L. Swanson, Makayla Tosh, Jennifer R. Wells, Rafael Díaz, Clara K Chow, Beatriz Alvarenga Gonzales, Skarlet Marcell Vásquez, Petr Janský, Radovan Dušek, Pierre Coriat, Mária Wittmann, Gerald Yonga, Nandini Mathur, Elena Seletti, Germán Málaga, Bernadette A Tumanan-Mendoza, Maria Pamela A. Tagle, Pablo Alonso‐Coello, Ekaterine Popova, Martin Shields, Yannick Le Manach, Paul Moayyedi, Sander van Zanten, Edith Fleischmann, Amit X. Garg, Kamilu M. Karaye, Edward O. McFalls, Alben Sigamani, Emilie P. Belley‐Côté, Grzegorz Biedroń, Flávia K. Borges, Steffan Frosi Stella, Darryl P. Leong, Jessica Spence, Allen Tran, Katarzyna Wawrzycka‐Adamczyk, Stephen Yang, Terence Yung, D. George Wyse, Davy Cheng, David E. Johnstone, George A. Wells, Philip Joseph, Ameen Patel, Krysten Gregus, Kelly Lawrence, Lindsay DoHarris, David Conen, Jason Pui Yin Cheung, Jim Douketis, Douglas Wright, Spencer Wikkerink, William Dechert, Mohamed Panju, Khalid Azzam, Theodore Rapanos, Tomas Van helder, Anjali Shroff, Jacqueline Hare, Biniam Kidane, Thang Huy Nguyen, Larissa Leydier, Vanessa Bayaraa, Joel L. Parlow, Deborah DuMerton, Amar Thakrar, Jessica Shelley, B. Deligne, Roberta Daila Carling, Marko Mrkobrada, George K. Dresser, Michael J. Jacka, David Hornstein, Gerrit B. Winkelaar, Zoeb Hussain Haider, Pravina Prashant Lanjewar, Valsamma Varughese, Rajneesh Calton, Hemani Ahuja, Preetha George, Ambika Sharma, Keyur S. Bhatt, Dhaval Mangukiya, Karshan Nandaniya, Viral Vasantrai Parekh, Ashok Bhaskaran Pillai, Vidya Menon, Sanjay C Desai, Ravinder Singh Sidhu, Sandeep Kumar Gupta, R. George, T.R. Gurunath, Leanne Drummond, Alexandra Torborg, Belinda Kusel, Prebashini Naidoo, D.P. Naidoo, Chantal Rajah, Zane Farina, Richard P von Rahden, Simphiwe Gumede, Chishala Chishala, Ettienne Coetzee, Robert A. Dyer, Johan Diedericks, Piotr Bielański, Bogusz Kaczmarek, Dorota Studzińska, Maciej Zaniewski, Marek Józef Libura, Aurelia Sega, Jakub Salwa, Mateusz Kózka, Jacek Górka, Anna Włudarczyk, Ilona Nowak, Paweł Grudzień, Jaroslaw Gucwa, M Słowiaczek, Paweł Dobosz, Ismail Gögenür, Jens Eriksen, Tine Borup, Tove Kirkegaard, Dan Isbye, Asger Sonne, Lars S. Rasmussen, Sofie T Pedersen, Hannibal Troensegaard, Camilla Lundgreen Duus, Benedikte Møhl Halle, Ossian Gundel, Katrine Feldballe Bernholm, Kristian Martinsen, Søren Pedersen, Theis Skovsgaard Itenov, Elena Camio, Carles Vázquez, Silvia Matarín, Esther Cano, Jesús Álvarez‐García, Inmaculada India, Aránzazu González Osuna, Marc Vives, Elena Rosselló, Ana B. Serrano, Maurizio Turiel, Lorenzo Drago, Chiara Colombo, Federica Marra, Lucio Mos, Franco Arteni, Rosalba Lembo, Alessandro Ortalda, Simonetta Passarani, Zhirajr Mokini, Estêvão Lanna Figueiredo, Gustavo Fonseca Werner, João Luiz Fernandes Petriz, Lília Nigro Maia, Ricardo Reinaldo Bergo, Dalton Bertolim Précoma, José Francisco Kerr Saraiva, Oscar Gómez Vilamajó, Eduardo Allegrini, Mariano Benzadón, Maria Leonor Parody, Ernesto Duronto, Adrián Ingaramo, Gustavo Parra, Danny Novoa, Scott Miller, Sabu Thomas, Sudhakar P. Karlapudi, Mohamad Bourji, Subhash Banerjee, Anita Gupta, Isaac O. Opole, Michal Fischer, Victor Lecaros Mendoza, Eugenio Borja Reyes, R. Pierson, Martin O. Shields, Vincent Piriou, Kai Zacharowski, Aida Rotta, Main Paper, Prashant Rahate, Bogani Mayosi, Mike Sharma
Bibliographic record
VenueThe Lancet · 2018
Typearticle
Languageen
FieldMedicine
TopicCardiac, Anesthesia and Surgical Outcomes
Canadian institutionsUniversity of ManitobaPopulation Health Research InstituteUniversité de MontréalImpactQueen's UniversityMcMaster University
FundersCanadian Institutes of Health Research
KeywordsDabigatranMedicinePlaceboRandomized controlled trialCardiac surgeryInternal medicineAnesthesiaCardiologyAtrial fibrillationWarfarinAlternative medicine
Abstract
No abstract in any covered source. Its absence is recorded, not treated as a negative.
No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.005
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Randomized trial · Consensus signal: Randomized trial
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.007
Threshold uncertainty score0.023
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.005 |
| Meta-epidemiology (narrow) | 0.002 | 0.001 |
| Meta-epidemiology (broad) | 0.005 | 0.005 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.002 | 0.002 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.003 | 0.003 |
| Insufficient payload (model declined to judge) | 0.007 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
Opus teacher head0.011
GPT teacher head0.260
Teacher spread0.249 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
The models applied no category: nothing in the taxonomy fit this work.
Study designRandomized trial
Domainnot available
GenreEmpirical
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".
Quick stats
Citations325
Published2018
Admission routes2
Has abstractno