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Electrochemical strategies for C–H functionalization and C–N bond formation

2018· review· en· 994 citations· W2808363512 on OpenAlex· 10.1039/c7cs00619e

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Abstract

Conventional methods for carrying out carbon-hydrogen functionalization and carbon-nitrogen bond formation are typically conducted at elevated temperatures, and rely on expensive catalysts as well as the use of stoichiometric, and perhaps toxic, oxidants. In this regard, electrochemical synthesis has recently been recognized as a sustainable and scalable strategy for the construction of challenging carbon-carbon and carbon-heteroatom bonds. Here, electrosynthesis has proven to be an environmentally benign, highly effective and versatile platform for achieving a wide range of nonclassical bond disconnections via generation of radical intermediates under mild reaction conditions. This review provides an overview on the use of anodic electrochemical methods for expediting the development of carbon-hydrogen functionalization and carbon-nitrogen bond formation strategies. Emphasis is placed on methodology development and mechanistic insight and aims to provide inspiration for future synthetic applications in the field of electrosynthesis.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

The record

Venue
Chemical Society Reviews
Topic
Radical Photochemical Reactions
Field
Chemistry
Canadian institutions
Funders
VetenskapsrådetYork University
Keywords
Surface modificationElectrochemistryExpeditingChemistryCarbon fibersCombinatorial chemistryNanotechnologyMaterials scienceElectrodePhysical chemistry
Has abstract in OpenAlex
yes