DIPG-70. CLINICAL, RADIOLOGICAL, PATHOLOGICAL AND MOLECULAR CHARACTERISTICS OF CHILDREN <3 YEARS WITH DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG): A REPORT FROM THE INTERNATIONAL DIPG REGISTRY
Bibliographic record
Abstract
Children <3 years with DIPG are reported to have a higher rate of long-term survival (LTS, overall survival (OS) ≥24 months). In patients <3 years with centrally confirmed DIPG, we compared clinical, radiological, histological and molecular characteristics between LTS versus short-term survivors (STS <24 months). Data from children <3 years on the International DIPG Registry (IDIPGR) were analyzed. Among 782 DIPG patients, 53 were <3 years; 13 were excluded (3 without imaging, 10 “unlikely DIPG” on central review). Of the remaining 39 with at least 24-month follow-up, 10 (26%) were LTS. Among 29 patients who received therapy, 9 (31%) were LTS; median OS was 16 months (range: 2–123+ months); 27/29 (93%) received radiotherapy, including all treated LTS (9/9). Median OS among patients who did not receive therapy was 2 months, but included one LTS (37 months). LTS presented with longer symptom duration (p=0.004); tumor size, ring enhancement, necrosis and extra-pontine extension on MRI did not reach significance. Biopsy and/or autopsy was performed in 43% of patients; 50% had H3K27 mutations. Whole genome sequencing and RNA sequencing are being conducted to correlate key parameters (e.g. NTRK fusions, P53 mutations, H3K27 mutations, ACVR1) with outcome. In the largest series reported to date, children <3 years with centrally confirmed DIPG demonstrated a significantly higher rate of LTS and improved median OS. LTS were more likely to have longer duration of symptoms. Only 50% had H3K27 mutations. Final genomic analyses will be presented, and may reveal predictors of improved outcome.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".