Stability of meropenem in saline and dextrose solutions and compatibility with potassium chloride
Bibliographic record
Abstract
ABSTRACT Objectives: The stability and compatibility of meropenem, 50 mg and 2000 mg added to 50 mL of normal saline (NS) or 5% dextrose in water (D5W) was evaluated at -20°C and 4°C over 14 days and at 23°C over 36 hours. The stability and compatibility of meropenem in NS or D5W with potassium chloride (I0 mmol/mL and 40 mmol/mL, diluted in either NS or D5W) was also evaluated at 23°C over 36 hours. Methods: In addition to visual inspection and pH, the meropenem concentration of solution was determined by a stability-indicating liquid chromatographic method. Meropenem concentrations were considered acceptable if the concentration on any day of analysis was greater than 90% of the initial (day zero) concentration. Results: Meropenem is more stable in NS than in D5W. The more concentrated solutions degrade faster in NS. Temperature also significantly affects stability. Solutions stored at room temperature lost more than I0% within 24 hours, while at 4°C, solutions retained 90% of the initial concentration for 1 to 7 days. At -20°C, NS solutions retained 90% of the initial concentration for at least 11 days. Meropenem is compatible with potassium chloride (KCl) in concentrations of IO mmol/L and 40 mmol/L in NS and D5W at 23°C. The presence of KCl did not affect the stability of meropenem. No significant change in pH was observed during the study period. Conclusions: This study demonstrates that at least three factors: temperature, concentration and diluent (presence of dextrose) affect the stability of meropenem. Once reconstituted, meropenem is more stable when diluted in NS than D5W. Potassium chloride solutions are compatible with meropenem solutions and do not appear to alter the stability of meropenem. RESUME Objectifs : Evaluer la stabilite et la compatibilite du meropenem dans des proportions de 50 mg et 2000 mg dans 50 mL de solute physiologique normal (NS) de dextrose a 5% dans l'eau (D5W), a des temperatures de -20 °Cet de 4 °C durant 14 jour et de 23 °C durant 36 heures. La stabilite et la compatibilite du meropenem dans du NS ou du D5W avec du chlorure de potassium (1O mmol/mL et 40 mmol/mL, dilue dans du NS ou du D5W) ont aussi ete evaluees a une temperature de 23 °C durant 36 heures. Methodes : Outre l'inspection visuelle et la verification du pH, on a determine la concentration des solutions en meropenem, au moyen d'une epreuve destabilise par chromatographie liquide. Les concentrations en meropenem etaient considerees acceptables si a n'importe quel jour d'une analyse, elles etaient superieures a 90 % des concentrations initiales (au jour 0). Resultats : Le meropenem est plus stable dans le NS que dans le D5W Les solutions a concentration plus elevee se degradent plus rapidement dans le NS. La temperature affecte aussi grandement la stabilite. Les solutions entreposees a la temperature ambiante ont perdu plus de 1O % de leurs concentrations initiales en 24 heures, a lorsqu'entreposees a 4 °C elles ont conserve plus de 90 % de leurs concentrations initiales durant 1 a 7 jours. Les solutions de meropenem dans du NS, entreposees a 20 °C ont conserve 90 % de leur concentration initiale en meropenem pendant au moins 11 jours. Le meropenem est compatible avec le chlorure de potassium (KCI) dans des concentrations de 10 mmol/L et de 40 mmol/L dans du NS et du D5W a 23 °C. La presence de KCI n'a pas affecte la stabilite du meropenem. Aucun changement significatif du pH n'a ete observe au cours de la periode d'etude. Conclusions : Cette etude a demontre qu'au moins trois facteurs affectent la stabilite du meropenem : la temperature, la concentration et le diluent (presence de dextrose). Apres sa reconstitution, le meropenem est plus stable lorsqu'il est dilue dans du NS que dans du D5W. Les solutions de chlorure de potassium sont compatibles avec les solutions de meropenem et elles ne semble pas alterer la stabilite du meropenem.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".