Exertional Oxygen Requirements During Exercise Training in Advanced Interstitial Lung Disease
Bibliographic record
Abstract
PURPOSE: Little is known about the oxygen requirements during physical exertion or exercise in individuals with interstitial lung disease (ILD). This study examined exertional oxygen requirements, the relationships between exertional oxygen use, exercise capacity and aerobic training parameters, and predictors of change in exertional oxygen requirements during pulmonary rehabilitation (PR). METHODS: A retrospective study of lung transplant candidates with advanced ILD who underwent at least 4 wk of outpatient PR between 2004 and 2014 was undertaken. Data were extracted at baseline, 4 wk, and 6 mo. Exertional oxygen was prescribed during PR to support continuous, moderate-intensity aerobic training. RESULTS: The study cohort (n = 375) had a median age of 61 y (55-66 y), were 57% male, and most were diagnosed with idiopathic pulmonary fibrosis (n = 214). A variety of oxygen delivery systems were used and exertional oxygen requirements increased after 4 wk (0.5 [0.4-0.6] vs 0.5 [0.4-0.73], P < .001, n = 375) and 6 mo (0.44 [0.36-0.5] vs 0.5 [0.4-0.55], P < .001, n = 196) of PR. A higher exertional oxygen requirement was associated with lower 6-min walk distance and lower aerobic training intensity at all time points. There were no identified predictors of the change in exertional oxygen requirements. CONCLUSIONS: Individuals with advanced ILD had high exertional oxygen requirements to participate in moderate-intensity aerobic training, which increased over time. Exertional oxygen needs may affect exercise prescription and response during PR in ILD patients.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".