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Record W2810557289 · doi:10.1016/j.celrep.2018.05.093

A PQM-1-Mediated Response Triggers Transcellular Chaperone Signaling and Regulates Organismal Proteostasis

2018· article· en· W2810557289 on OpenAlexfundno aff
Daniel T. O’Brien, Laura Jones, Sarah C. Good, Jay Miles, M. S. Vijayabaskar, Rebecca Aston, Catrin E. Smith, David R. Westhead, Patricija van Oosten‐Hawle

Bibliographic record

VenueCell Reports · 2018
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGenetics, Aging, and Longevity in Model Organisms
Canadian institutionsnot available
FundersOffice of Research Infrastructure Programs, National Institutes of HealthBiotechnology and Biological Sciences Research CouncilMedical Research CouncilNational Institutes of HealthNational Centre for the Replacement Refinement and Reduction of Animals in ResearchNational Centre for the Replacement, Refinement and Reduction of Animals in ResearchMauritius Research CouncilMedical Research Council CanadaWellcome Trust
KeywordsProteostasisCell biologyBiologyInnate immune systemTranscription factorUnfolded protein responseSignal transductionChaperone (clinical)Transmembrane proteinHeat shock proteinBiochemistryImmunologyImmune systemEndoplasmic reticulumReceptorGene

Abstract

fetched live from OpenAlex

-associated toxicity. This may have powerful implications for the treatment of diseases related to proteostasis dysfunction.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.012
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.008
GPT teacher head0.205
Teacher spread0.198 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations72
Published2018
Admission routes1
Has abstractyes

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