SUSTAIN 6: Effekt von Semaglutid auf kardiovaskuläre Endpunkte im zeitlichen Verlauf bei Patienten mit Typ 2 Diabetes (Post-hoc Auswertung)
Bibliographic record
Abstract
Hintergrund: \n \nSemaglutid ist ein GLP-1 Analogon zur Behandlung des Typ 2 Diabetes (T2D). SUSTAIN 6 war eine kardiovaskuläre (CV) Endpunktstudie bei 3.297 Erwachsenen mit T2D und hohem CV Risiko. Semaglutid (0,5 oder 1,0 mg) s.c. zusätzlich zu Standardbehandlung führte zu einer signifikanten 26% Reduktion (Hazard Ratio [HR] 0,74; 95% Konfidenzintervall [CI] 0,58 – 0,95) des Risikos für ein primäres Ereignis des Endpunkts (CV Tod, nicht-tödlicher Myokardinfarkt [MI], nicht-tödlicher Schlaganfall) vs. Placebo, bedingt durch Reduktionen des Risikos für nicht-tödlichen MI (26%; HR 0,74; 95% CI 0,51 – 1,08) und nicht-tödlichen Schlaganfall (39%; HR 0,61; 95% CI 0,38 – 0,99).
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.001 |
| Meta-epidemiology (narrow) | 0.002 | 0.002 |
| Meta-epidemiology (broad) | 0.003 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.002 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.008 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; both teacher heads agree on what is shown here.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".