Cardiopulmonary, biomarkers, and vascular responses to acute hypoxia following cardiac transplantation
Bibliographic record
Abstract
Abstract Previous studies have suggested good adaptation of cardiac transplant ( CT x) recipients to exposure to a high altitude. No studies have investigated the cardiopulmonary and biomarker responses to acute hypoxic challenges following CT x. Thirty‐six CT x recipients and 17 age‐matched healthy controls ( HC ) were recruited. Sixteen (16) patients (42%) had cardiac allograft vasculopathy ( CAV ). Cardiopulmonary responses to maximal and submaximal exercise at 21% O 2 , 20‐minutes hypoxia (11.5% O 2 ), and following a 10‐minute exposure to 11.5% O 2 using 30% of peak power output were completed. Vascular endothelial growth factor ( VEGF ), interleukin‐6 ( IL ‐6), suppression of tumorigenicity 2 ( ST 2) were measured at baseline and at peak stress. Endothelial peripheral function was assessed using near‐infrared spectroscopy. Compared with HC , CT x presented a lesser O 2 desaturation both at rest (−19.4 ± 6.8 [ CT x] vs −24.2 ± 6.0% O 2 [ HC ], P < 0.05) and following exercise (−23.2 ± 4.9 [ CT x] vs −26.2 ± 4.7% O 2 [ HC ], P < 0.05). CT x patients exhibited a significant decrease in peak oxygen uptake. IL ‐6 and VEGF levels were significantly higher in CT x recipients in basal conditions but did not change in response to acute stress. CT x patients exhibit a favorable ventilatory and overall response to hypoxic stress. These data provide further insights on the good adaptability of CT x to exposure to high altitude.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".