An Assessment for the Risk of Herb-drug Interactions in Adverse Event Reports (AERs) Related to Natural Health Products and Medications Used for Attention Deficit Hyperactivity Disorder
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Concurrent use of Natural Health Products (NHPs) is common in patients using medication for Attention Deficit Hyperactivity Disorder (ADHD). NHPs are generally recognized as safe, however some can lead to adverse events, either alone or when taken concurrently with drugs. Adverse event reports (AERs) submitted to regulatory agencies can be used to evaluate safety of NHPs. Our goal is to identify AERs relating to potential herb-drug interactions and assess them for quality and causality, and to use complementary in-vitro assays to evaluate bioactivity. We systemically searched the FDable database for AERs involving commonly used NHPs with ADHD drugs (stimulants and non-stimulants). We obtained 53 reports from U.S. Food and Drug Administration through the Freedom of Information Act and evaluated their quality using multiple validated scales. We identified 8 AERs using less than 3 substances for causality assessments (4 St. John's Wort, 2 ginkgo biloba, 2 evening primrose oil) completed by four experts using 3 tools. Consensus of causality assessments ranged from doubtful to possible risk of an interaction, with an agreement on lack of information present in the AERs. In-vitro inhibition assays were performed with recombinant enzymes (florescence based) and human liver microsomes (using high-performance liquid chromatography) to determine effects of select NHPs on enzymes involved in ADHD drug metabolism. Preliminary data reveal St. John's wort and ginkgo biloba inhibit recombinant carboxylesterase 1 and that St. John's wort reduces human liver microsome-mediated metabolism of methylphenidate. Overall, causality assessments from high quality reports in conjunction with in-vitro data can aid in evidence-based decision making and fill imperative gaps in the safety of NHPs.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it