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Record W2884222022 · doi:10.1055/s-0038-1644912

Measurement Science for Enhanced Cannabis Testing

2018· article· en· W2884222022 on OpenAlex
JE Melanson, Garnet McRae, PM Le, Jennifer Bates

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.
aboutThe title or abstract carries a Canadian signal from the geographic lexicon.

Bibliographic record

VenuePlanta Medica International Open · 2018
Typearticle
Languageen
FieldMedicine
TopicCannabis and Cannabinoid Research
Canadian institutionsNational Research Council Canada
Fundersnot available
KeywordsCannabisCertificationCertified reference materialsStandardizationTraceabilityComputer scienceEngineeringMedicineChemistryPolitical scienceChromatographyPsychiatry

Abstract

fetched live from OpenAlex

Advancements in measurement science are vital in assuring the quality and safety of Canada's rapidly expanding cannabis industry. Reports of high variability in results between testing laboratories, in addition to several medical cannabis recalls, have highlighted the need for standards in cannabis testing. The National Research Council, as Canada's National Metrology Institute, is addressing this challenge through the promotion of documentary standards for cannabis testing methods and the development of cannabis certified reference materials (CRMs). These standards will ensure accuracy and consistency of testing results, assist licensed cannabis producers in achieving regulatory requirements, and ultimately promote confidence in the regulated cannabis industry. This presentation will highlight recent advancements in metrology in support of the cannabis industry. Specifically, a liquid chromatography – tandem mass spectrometry (LC-MS/MS) method for cannabinoids will be described, which is being proposed as a candidate ASTM International standard method. A pesticide method using liquid chromatography – high resolution mass spectrometry (LC-HRMS) will also be discussed. The presentation will also highlight progress on the development of a cannabis CRM (NRC MARI-1) to be certified for major cannabinoids and select contaminants. The production and certification will discussed, including the establishment of SI-traceability through the purity assignment of cannabinoid standards by quantitative nuclear magnetic resonance spectroscopy (qNMR). The availability of a cannabis CRM will facilitate method validation for cannabis testing laboratories and allow laboratories to assess their entire method, from extraction to analysis.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.004
metaresearch head score (Gemma)0.007
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.883
Threshold uncertainty score0.895

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0040.007
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.001
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.089
GPT teacher head0.392
Teacher spread0.302 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it