Studies of photophysical characteristics and in vitro photocytotoxicity of photosensitizer dimegine
Bibliographic record
Abstract
In the represented work, a study of a low-toxic photosensitizer of dimegine (disodium salt of 2,4-di (alphamethoxyethyl) -deuteroporphyrin-IX ”) was carried out. The quantum yields of singlet oxygen generation and fluorescence as the main photophysical characteristics of the photosensitizer were studied. To ensure the stability of dimegine upon irradiation, its photobleaching coefficient was investigated. The photocytotoxicity was studied on four cell lines: U87 – human primary glioblastoma cell line, RG2 – rat glioma cell lines, HT1372 – human bladder cancer cell line, AY27 – rat bladder carcinoma cell line. The same cell lines were used in cells distribution studies. Results of this research have shown high effectiveness of photodynamic therapy with dimegine under irradiation by light with a wavelength of 530 nm and 625 nm. Images, received after photosensitizer distribution studies, demonstrated dimegine’s primary location in cell's organelles, thereby allowing to make the assumption about domination of apoptosis over necrosis as mechanism of cell death.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".