Studies of photophysical characteristics and in vitro photocytotoxicity of photosensitizer dimegine
Bibliographic record
Abstract
In the represented work, a study of a low-toxic photosensitizer of dimegine (disodium salt of 2,4-di (alphamethoxyethyl) -deuteroporphyrin-IX ”) was carried out. The quantum yields of singlet oxygen generation and fluorescence as the main photophysical characteristics of the photosensitizer were studied. To ensure the stability of dimegine upon irradiation, its photobleaching coefficient was investigated. The photocytotoxicity was studied on four cell lines: U87 – human primary glioblastoma cell line, RG2 – rat glioma cell lines, HT1372 – human bladder cancer cell line, AY27 – rat bladder carcinoma cell line. The same cell lines were used in cells distribution studies. Results of this research have shown high effectiveness of photodynamic therapy with dimegine under irradiation by light with a wavelength of 530 nm and 625 nm. Images, received after photosensitizer distribution studies, demonstrated dimegine’s primary location in cell's organelles, thereby allowing to make the assumption about domination of apoptosis over necrosis as mechanism of cell death.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".