Facile Strategies to Synthesize Dual Location Dual Acidic pH/Reduction-Responsive Degradable Block Copolymers Bearing Acetal/Disulfide Block Junctions and Disulfide Pendants
Bibliographic record
Abstract
We report new dual acidic pH/reduction-responsive degradable amphiphilic block copolymers featured with dual acidic pH-labile acetal linkage and a reductively-cleavable disulfide bond at the hydrophilic/hydrophobic block junction as well as pendant disulfide bonds in the hydrophobic block. Centered on the use of a macroinitiator approach, three strategies utilize the combination of atom transfer radical polymerization and reversible addition fragmentation chain transfer polymerization in a sequential or concurrent mechanism, along with facile coupling reactions. Combined structural analysis with dual-stimuli-responsive degradation investigation allows better understanding of the architectures and orthogonalities of the formed block copolymers as a diblock or a triblock copolymer. Our study presents the development of effective synthetic strategies to well-defined multifunctional amphiphilic block copolymers that exhibit dual-stimuli-responsive degradation at dual location (called the DL-DSRD strategy), thus potentially promising as nanoassemblies for effective drug delivery.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".