MétaCan
Menu
Back to cohort
Record W2888416545 · doi:10.1038/s41593-018-0206-1

GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal effect of schizophrenia liability

2018· article· en· W2888416545 on OpenAlexaff
Joëlle A. Pasman, Karin J. H. Verweij, Zachary F. Gerring, Sven Stringer, Sandra Sanchez‐Roige, Jorien L. Treur, Abdel Abdellaoui, Michel G. Nivard, Bart M. L. Baselmans, Jue‐Sheng Ong, Hill F. Ip, Matthijs D. van der Zee, Meike Bartels, Felix R. Day, Pierre Fontanillas, Sarah L. Elson, Harriet de Wit, Lea K. Davis, James MacKillop, Jaime Derringer, Susan Branje, Catharina A. Hartman, Andrew C. Heath, P.A.C. van Lier, Pamela A. F. Madden, Reedik Mägi, Wim Meeus, Grant W. Montgomery, Albertine J. Oldehinkel, Zdenka Pausová, Josep Antoni Ramos‐Quiroga, Tomáš Paus, Marta Ribasés, Jaakko Kaprio, Marco P. Boks, Jordana T. Bell, Tim D. Spector, Joel Gelernter, Dorret I. Boomsma, Nicholas G. Martin, Stuart MacGregor, John R. B. Perry, Abraham A. Palmer, Daniëlle Posthuma, Marcus R. Munafò, Nathan A. Gillespie, Eske M. Derks, Jacqueline M. Vink

Bibliographic record

VenueNature Neuroscience · 2018
Typearticle
Languageen
FieldMedicine
TopicCannabis and Cannabinoid Research
Canadian institutionsHospital for Sick ChildrenUniversity of TorontoMcMaster UniversityBaycrest HospitalSt. Joseph’s Healthcare Hamilton
FundersNational Institute on Drug AbuseNational Institute on Alcohol Abuse and AlcoholismEuropean Regional Development FundNational Institute of Mental HealthMedical Research CouncilEuropean CommissionNational Institute for Health and Care ResearchNederlandse Organisatie voor Wetenschappelijk OnderzoekVrije Universiteit AmsterdamNational Institutes of HealthStichting Volksbond Rotterdam
KeywordsMendelian randomizationGenome-wide association studyCannabisSchizophrenia (object-oriented programming)PsychiatrySingle-nucleotide polymorphismPsychologyGenetic associationGeneticsMedicineBiologyGeneGenotypeGenetic variants

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.003
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.011
Threshold uncertainty score0.023

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.003
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0010.001
Science and technology studies0.0010.001
Scholarly communication0.0010.000
Open science0.0010.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0040.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.006
GPT teacher head0.278
Teacher spread0.272 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations551
Published2018
Admission routes1
Has abstractno

Explore more

Same venueNature NeuroscienceSame topicCannabis and Cannabinoid ResearchFrench-language works237,207