Regadenoson Stress in Patients with Airways Disease and Pulmonary Hypertension
Bibliographic record
Abstract
Regadenoson is an increasingly used pharmacological stress agent for myocardial perfusion imaging (MPI) that has an important advantage over other primary coronary vasodilators. Both adenosine and dipyridamole have a non-selective action on the adenosine receptors and can therefore induce bronchospasm in susceptible individuals. In contrast, regadenoson acts selectively on the adenosine receptor subtype responsible for the coronary vasodilator effect of these agents with little, if any, activity on adenosine receptor-mediated bronchoconstrictive pathways. This gives regadenoson an advantage over other vasodilators in the management of patients with obstructive airways disease undergoing stress MPI. There is compelling evidence for the improved tolerability of regadenoson stress in patients with a history of bronchial hyperreactivity. Moreover, regadenoson has proved to be safe in advanced forms of lung disease and is currently the preferred stress agent in these patients. Experience on the use of regadenoson in poorly controlled asthma or chronic obstructive pulmonary disease (COPD) is limited, and thus caution must be exercised when considering regadenoson stress in patients with suspected persistent or clinically manifest airway obstruction.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".