P020 <break /> Extracellular Matrix Driven Mesenchymal Cell Differentiation
Bibliographic record
Abstract
Idiopathic pulmonary fibrosis (IPF) is a chronic disease, characterized by progressive scarring of lung tissue. IPF prognosis is poor, with most patients succumbing to the illness at a rate comparable to aggressive cancers. The causes of IPF remain elusive and there is no curative therapy. The key component contributing to the development and progression of IPF is the accumulation/recruitment of lung myofibroblasts leading to excess deposition of extracellular matrix (ECM) proteins. The effect of the ECM properties (composition and stiffness) on the phenotype and regulation of pulmonary cells is yet to be fully elucidated. However, there is evidence suggesting increased ECM deposition may promote differentiation of cells into myofibroblasts; therefore, progressing the disease in an exponential manner. Lungs were harvested from control Sprague-Dawley rats and decellularized. They were then reseeded with primary fibroblast from AdTGF-β treated rats (D7, D28, D49) to assess their reversibility. The degree and rate of reversibility were assessed using Western blots, rtPCR, and immunofluorescence for α-SMA, collagen, and TGF- β.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.003 | 0.003 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; both teacher heads agree on what is shown here.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".