Multimodal Enhancement of Remyelination by Exercise with a Pivotal Role for Oligodendroglial PGC1α
Why is this work in the frame?
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
The three-model screen
all 1,000 screened works →All three models called this out of scope.
Mouse study of exercise-enhanced remyelination; neuroscience.
This is a biomedical experiment on exercise and remyelination, not a study of research practice.
Neuroscience mouse study of exercise-enhanced remyelination mechanisms.
Abstract
Remyelination is a multistep regenerative process that results in the reformation of myelin sheaths around demyelinated axons and is a critical therapeutic target. Here we show that immediate access to a running wheel following toxin-induced demyelination in mice enhances oligodendrogenesis, the rate of remyelination, and the proportion of remyelinated axons. RNA sequencing suggests broad activation of pro-remyelination pathways including phagocytosis by exercise and highlights peroxisome proliferator-activated receptor gamma co-activator 1-alpha (PGC1α) activation. By immunohistochemistry and cell type-specific conditional deletion, we confirmed PGC1α within oligodendrocytes as a transiently expressed factor required for the rate of myelin thickening by exercise. We validated the exercise-enhanced clearance of inhibitory lipid debris from lesions. Finally, exercise works in parallel with the remyelinating medication clemastine to produce complete remyelination of lesions. Our study demonstrates physical activity as an integrative means to enhance remyelination and details a multimodal mechanism including the pivotal PGC1α-dependent enhancement of myelin thickness.
Stored with the screening record, where it is evidence for the labels above.
The record
- Venue
- Cell Reports
- Topic
- Neurogenesis and neuroplasticity mechanisms
- Field
- Neuroscience
- Canadian institutions
- University of LethbridgeUniversity of Calgary
- Funders
- Multiple Sclerosis Society of CanadaCanadian Institutes of Health ResearchAlberta Innovates - Health Solutions
- Keywords
- RemyelinationMyelinActivator (genetics)NeuroscienceReceptorBiologyCell biologyMedicineInternal medicineCentral nervous system
- Has abstract in OpenAlex
- yes