Peptides meet ubiquitin: Simple interactions regulating complex cell signaling
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Abstract The interplay between the ubiquitin proteasome system (UPS) and diverse peptide motifs controls almost every aspect of cell homeostasis. To achieve such an impressive functional diversity nature has evolved hundreds of different peptide motifs that interact with proteins in the UPS and ubiquitin itself to generate an immense network of interactions. Short peptides embedded in proteins are involved in controlling the intracellular levels of proteins as well as in the translation of ubiquitin signals into biochemical events. Therefore, it is not surprising that dysregulation of such interactions is associated with many diseases, including metabolic syndromes, neurodegenerative disorders, and cancer. We review the structural and functional features of peptide motifs interacting with the UPS and their use for generating protein‐protein interaction inhibitors.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it