Abstract 13670: Vitamin D Deficiency is Associated With Increased Risk of Subclinical Myocardial Damage in Younger but not Older Adults: The Atherosclerosis Risk in Communities (ARIC) Study
Bibliographic record
Abstract
Background: Vitamin D deficiency has been associated with increased risk of coronary heart disease (CHD) and heart failure (HF) in epidemiologic studies. It is unknown whether low 25-hydroxyvitamin D [25(OH)D] is associated with subclinical myocardial damage as assessed by high-sensitivity cardiac troponin T (hs-cTnT), and whether this association varies by age or race. Methods: We studied 11,311 white and black ARIC participants (median age 56 yrs) free of prevalent CHD and HF who had 25(OH)D and cTnT measured at baseline (1990-1992). 8,990 participants had a repeat hs-cTnT measurement 6 years later (1996-1998). We used logistic and Poisson regression models to characterize the cross-sectional association of 25(OH)D categories with elevated hs-cTnT (≥14 ng/L) and the prospective association with incident elevated cTnT at followup (among those without elevated hs-cTnT at baseline, n=8733). We tested for interaction by age and race. Results: The prevalence of elevated hs-cTnT at baseline was 4% (n=433). After adjustment for age/sex/race, 25(OH)D deficiency (<20 ng/ml) was cross-sectionally associated with elevated hs-cTnT [OR 1.35, 95% CI 1.01-1.81]; however findings were no longer significant after adjustment for behavioral/lifestyle factors [OR 1.17, 0.87-1.59]. At followup, there were 517 cases of incident elevated hs-cTnT. 25(OH)D was not associated with incident troponin elevation in the overall cohort, but significant interactions were present by age (p-interaction 0.01). Low 25(OH)D was associated with incident elevated hs-cTnT in younger but not older adults ( Table ). There were no interactions by race. Conclusions: The association of low 25(OH)D with incident elevated hs-cTnT varies by age. If these associations are causal, further research is needed to understand mechanisms by which low 25(OH)D confers subclinical myocardial damage among younger but not older adults and whether vitamin D supplementation can prevent myocardial damage.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.002 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".