Impact of exercise on psychological burden in adult survivors of childhood cancer: A report from the Childhood Cancer Survivor Study (CCSS).
Bibliographic record
Abstract
10513 Background: Adult survivors of childhood cancer are at risk for adverse psychological outcomes. Whether exercise can attenuate this risk is unknown. Methods: Using a longitudinal design, 6199 CCSS participants (median [range] age 34 years [22-54] and median [range] age at diagnosis 10 years [0-21]) completed a baseline questionnaire assessing vigorous exercise, medical and psychological conditions. Psychological outcomes were evaluated in a subsequent questionnaire a median of 7.8 years later (range 0.1-10). Primary outcome was overall psychological burden, defined as: symptom level above the 90th percentile of population norms on the Brief Symptom Inventory-18 for depression, anxiety, or somatization ; cancer-related pain; cognitive impairment; or poor quality of life. Log-binomial regression estimated associations between exercise [total metabolic equivalent-hrs.wk-1 (MET-hrs.wk-1)] and these outcomes adjusting for cancer diagnosis/treatment, demographics, and baseline medical/psychological illness. Results: The prevalence of overall psychological burden at follow-up was 71.3%. The prevalence of depression was 11.4%, anxiety 7.4%, and somatization 13.9%. Among those not engaged in vigorous exercise, the prevalence of overall psychological burden was 75.9%, compared to 68.6% in those who exercised ≥3 MET-hrs.wk-1 (p < 0.001). Compared to 0 MET-hrs.wk-1 of vigorous exercise, the adjusted prevalence ratio (PR) for overall psychological burden was 0.98 (95% CI, 0.95-1.01) for 3-6 MET-hrs.wk-1, 0.93 (95% CI, 0.90-0.96) for 9-12 MET-hrs.wk-1, and 0.94 (95% CI, 0.90-0.98) for 15-21 MET-hrs.wk-1. Compared to not reporting vigorous exercise, 9 to 12 MET-hrs.wk-1 was associated with an adjusted PR of 0.76 (95% CI, 0.62-0.93; p = 0.004) for depression and 0.79 (95% CI, 0.66-0.94; p = 0.003) for somatization. Vigorous exercise was associated with higher cognitive function in domains of task completion, organization, and working memory (p’s < 0.05) but was not associated with cancer pain or quality of life. Conclusions: Vigorous exercise is associated with lower psychological burden and less cognitive impairment in long-term survivors of childhood cancer.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".