P1‐017: IMPROVEMENT OF THE PSYCHOLOGICAL PROFILE OF OLDER ADULTS WITH AMNESTIC MILD COGNITIVE IMPAIRMENT (AMCI) BENEFITS SUBJECTIVE, BUT NOT OBJECTIVE, COGNITION
Bibliographic record
Abstract
Older adults with aMCI present memory and attentional impairments often in conjunction with depressive or anxious symptoms. Examining the links between these clusters of symptoms appears warranted since cognitive complaints worsen with depression and anxiety, and both objective and subjective cognitive decline heighten the risk of developing AD. This study used mindfulness- and psychoeducation- based interventions first to ameliorate mood and anxiety in older adults with aMCI, and second to expose the associations between psychological changes and objective and subjective cognitive changes. In this single-blind randomised-controlled trial, 41 participants with aMCI were assigned to an 8-week Mindfulness-Based Intervention (MBI; n=20) or a Psychoeducation-based intervention (PBI; n=21) providing, respectively, mindfulness meditation training and psychoeducation about memory and aging. Pre- and post- intervention participants were administered self-rated scales measuring depressive and anxious symptoms, ruminations and worries, self-perceived cognitive difficulties, along with computerized verbal memory and attention tasks. Repeated measures ANOVAs investigated the effect of the interventions on psychological variables. Pearson correlation analyses examined the associations between psychological and cognitive measures. ANOVAs revealed significant Time effects for depressive (p=.044) and anxious (p=.024) symptoms, ruminations (p=.050), and worries (p=.007). Significant or marginally significant correlates of depressive symptoms decline were less subjective difficulties related to memory (r=.31, p=.053), and attention (r=.37, p=.017), and less objectively measured post-error slowing (PES; r=.43, p=.021) on the Sustained Attention to Response Task. Less worries correlated with a decrease of subjective difficulties with memory (r=.32, p=.044) and attention (r=.45, p=.003). Anxiety and ruminations were not correlated to any objective or subjective cognitive changes. Patterns of significant results were similar when analyses were conducted separately for both interventions. Both interventions yielded benefits for all psychological variables. Relief of depressive symptoms and worries is indicative of subjective cognitive improvements in older adults with aMCI after undergoing an MBI or a PBI. Although contributing to the risk of cognitive decline, psychological symptoms alleviation does not seem to influence the status of objective cognitive symptoms after an intervention. Future research should investigate the impact of psychological benefits on cognitive decline and its potential to delay AD diagnosis in the long-term.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.005 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".