P2‐357: ASSOCIATION BETWEEN SLEEP DISTURBANCE AND MEDIAL TEMPORAL LOBE STRUCTURES IN MILD COGNITIVE IMPAIRMENT
Bibliographic record
Abstract
Neuropsychiatric symptoms (NPS) in older adults with mild cognitive impairment (MCI) increase the risk of developing Alzheimer's disease (AD) but the underlying neural mechanisms are unknown. As part of an ongoing dementia prevention trial, we examined the association between NPS relevant to depression and anxiety and AD-related structural neuroimaging biomarkers in older adults with MCI but no lifetime history of depression. We hypothesized that greater NPS severity would be associated with decreased MTL volume. Participants were 45 older adults (mean age 75(7.5) years, mean MoCA= 23.5(2.4)) with DSM5 Mild Neurocognitive Disorder without current or previous history of depression and who were enrolled in PACt-MD, a clinical trial combining brain stimulation and cognitive remediation for older adults at risk for AD. NPS were assessed using the informant-based Neuropsychiatric Inventory Questionnaire (NPI-Q) at baseline. High resolution T1-weighted structural MRI scans were acquired at 3Tesla. Regions-of-interest (ROIs) were extracted using FreeSurfer and included hippocampal (HC), amygdalar, and entorhinal cortex (ERC) volumes, and ERC-thickness. Correlational analyses were performed between ROIs and severity ratings for the following NPI-Q subscales: depression, anxiety, apathy, irritability, night-time behaviours, and appetite. Depression was the most frequently reported NPS (33%), followed by night-time behaviors (31%), irritability (24%), apathy (22%), appetite change (22%) and anxiety (13%). After applying a Bonferroni correction for multiple comparisons, only NPI-Q severity ratings for night-time behaviors remained significantly correlated with ROIs. These regions were bilateral HC, left amygdala and left ERC-thickness (all p ≤ 0.001). Preliminary findings indicate robust correlations between sleep disruption and MTL volumes in older adults with MCI but no lifetime history of depression. These findings extend the current literature which suggests a bidirectional relationship between sleep disturbance and AD pathogenesis, potentially through effects on accumulation of cerebral beta amyloid protein (1). Given there is evidence that melatonin may improve cognitive function and sleep quality in MCI (2), the present results support the need for further research on the potential impact of sleep disturbance and sleep interventions on progression of AD in older adults with MCI. References: 1. Shi et al. (2017). Sleep Medicine Reviews., 2. Cardinali DP.(2012). Am J Neurodegener Dis.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".