Abstract 160: Outcomes and Relationship to Time: Alteplase Administration in Patients With Large Vessel Occlusion in Non-intervention Group of the Hermes Collaboration
Bibliographic record
Abstract
Background: Data on outcomes and time effects of intravenous alteplase on outcome of patients with documented large vessel occlusion (LVO) are scarce. Aim: To define the effect of onset to treatment time (OTT) on functional outcomes and mortality among patients in the non-interventional arm of endovascular stroke trials. Methods: Individual patient-level data from the HERMES collaboration were pooled from seven trials that randomized patients with proven LVO to mechanical thrombectomy + best medical therapy vs. best medical therapy alone. In this analysis only patients who received alteplase directly at the endovascular hospital were included. Primary outcome was degree of disability (mRS distribution) at 3 months. Secondary outcomes included functional independence (mRS 0-2) at 3 months, mortality by 3 months, and symptomatic intracranial hemorrhage (sICH). Results: Among 893 patients in the control arms, 601 received alteplase at the endovascular hospital. The mean age was 66.0 years (SD 13.9), 50% were women, and median NIHSS was 17. 82% were treated within 3 hours from onset and 17% between 3 and 4.5 hours. SICH was observed in 20/585 (3.4%), 3.5% with OTT within 3h vs 3.2% with OTT 3-4.5 hours, p = 1.00. For each 60-minute delay in therapy the cOR for improvement on the mRS was 0.80 (95% CI 0.68 to 0.95, p=0.01) (Figure-A). For each 60-minute delay, the OR for functional independence (mRS 0-2) was 0.82 (95%CI, 0.66 to 1.03, Figure-B). There was no time effect on mortality (cOR, 0.99 (95%CI, 0.79 to 1.23). The reduction in treatment effect by time was not modified by age, baseline NIHSS score, baseline ASPECTS score or occlusion location (p interaction =0.21, 0.81, 0.88, 0.67 respectively). Conclusion: Faster intravenous thrombolysis delivery is associated with better functional recovery in patients with LVO not destined to receive mechanical thrombectomy. Figure legend: A: 90-day functional outcomes stratified by OTT. B: Proportion of mRS 0-2 the 90-day against OTT
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.013 | 0.026 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.002 | 0.003 |
| Bibliometrics | 0.001 | 0.002 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.002 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".