2165. Risk Factors for CPE Colonization in Household Contacts of CPE Colonized/Infected Patients
Bibliographic record
Abstract
Carbapenemase-producing Enterobacteriaceae (CPE) are a global threat. Risk of transmission of CPE in households remains poorly understood Population-based surveillance for CPE colonization/infection is conducted in Toronto/Peel Region, Canada. In households with ≥1 consenting household contact (HC), groin, rectal swabs and urine samples are submitted every 3 months for both IC and HC until the IC has three consecutive negative swab sets. Swabs/urines are incubated overnight in BHI, direct PCR for carbapenemase genes is performed; specimens positive for PCR are then cultured. Eighty-five households and 150 HC have been enrolled. Most common species/gene combinations in IC are: E. coli/NDM (33), E. coli/OXA48 (15), Klebsiella spp./NDM (11). HCs have a median of eight swabs (range 2–14). 12 (8%) HCs were colonized with CPE (median 1.5 pos samples, range 1–8). IC and HC had same gene in 11(92%) cases, and same species/gene in seven (58%) cases. NDM+OXA48 ICs were more likely to have CPE colonized HC, see table. CPE colonized HC were older, more likely to be the IC’s spouse (OR 32, 95% CI 4–260), and more likely to have travelled outside Canada (OR 9.7, 95% CI 1.2–78). HC colonization with CPE is uncommon, but not rare, and may be associated with either household transmission, or co-exposure of HC and IC via travel. Spouses are most often colonized. S. Poutanen, MERCK: Scientific Advisor, Speaker honorarium; COPAN: Speaker(but not part of a bureau), Travel reimbursement; Accelerate Diagnostics: Investigator, Research support; Bio-Rad: Investigator, Research support; bioMérieux: Investigator, Research support.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.030 | 0.003 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".