Human Blastocyst's Zona Pellucida segmentation via boosting ensemble of complementary learning
Why this work is in the frame
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Bibliographic record
Abstract
Characteristics of Zona Pellucida (ZP), particularly its thickness, is a key indicator of human blastocyst (day-5 embryo) quality. Therefore, ZP segmentation is an important step towards achieving automatic embryo quality assessment. In this paper, a novel approach based on boosting ensemble of hybrid complementary learning is proposed to segment Zona Pellucida in human blastocyst images. First, an inner-ZP localization method is proposed to separate the ZP from the heavily textured area inside a blastocyst. Then, a deep Hierarchical Neural Network (HiNN) is proposed to segment ZP area. The hierarchical nature of the proposed network enables learning features with respect to their spatial location in the embryo. Finally, a Self-supervised Image-Specific Refinement (SISR) strategy is proposed as a complementary step to boost the performance. The proposed system is a hybrid approach in the sense that the HiNN learns the intra-correlation among images, while the SISR takes into account the inter-correlation within the query image. Experimental results confirm that the proposed method is capable of identifying ZP area with average Precision, Recall, Accuracy and Jaccard Index of 85.2%, 92.0%, 95.6% and 78.1%, respectively. The proposed HiNN system outperforms state of the art by 4.9% in Precision, 11.2% in Recall, 3.6% in Accuracy and 10.7% in Jaccard Index.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it