Abstract 15575: Can Rhythm Control by Catheter Ablation Improve Exercise Capacity in Asymptomatic Patients With Chronic Atrial Fibrillation?
Bibliographic record
Abstract
Introduction: Radiofrequency catheter ablation (RFCA) for asymptomatic atrial fibrillation (AF) is not indicated due to limited data on it’s clinical efficacy. This study evaluated the change in oxygen kinetics and cardiopulmonary performance parameters after RFCA for asymptomatic (Canadian Cardiovascular Society-Severity of AF scores = 0) Chronic AF patients. Methods: A total of 57 patients with asymptomatic chronic AF (age 60 ± 9 year-old, 89.5% male, AF duration 51 ± 49 months) divided into 2 groups according to sinus rhythm conversion via RFCA: Group 1 (Rate control, n=32); Group 2 (Rhythm control, n=25). The patients who achieved sinus rhythm by antiarrhythmics (n=20) and cardioversion (n=4) were excluded. All underwent two times of treadmill cardiopulmonary exercise tests (modified Bruce protocol, Quark CPET®, COSMED, Italy) before and after each treatment (follow-up periods, 250 ± 181 days). Peak oxygen uptake (Peak VO2, ml/min/Kg) as aerobic capacity, O2-pulse at peak (ml/beat) for cardiovascular response, and the slope of the increase in ventilation to the increase in CO2 output (VE-VCO2 slope) for gas exchange were compared. Results: The Group 1 patients were older (62 ± 7 vs. 57 ± 10 year-old) and had longer duration of AF (63 ± 52 vs. 36 ± 39 months) than the Group 2 patients. The O2-pulse at peak were much increased in Group 2 during follow-up periods (Group 1, from 10.0 ± 3.1 to 10.6 ± 3.1, P=0.137; Group 2, 12.1 ± 3.8 to 15.4 ± 3.8, P=0.003). During exercise, maximal exercise heart rate was significantly lower in Group 2 after treatment (Group 1, 162±25 vs. Group 2, 128±29 bpm, P<0.001). However, the value of Peak VO2 and VE-VCO2 slope were not different between before and after treatment, and between 2 groups. Conclusion: The results from the present study indicate that improvement of maximal aerobic capacity and exercise tolerance are negligible in asymptomatic patients with chronic AF following successful catheter ablation.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".