Pilot Study for Examination of Injection Site Trauma and Injection Material Pathway Imaging through a Human Analog System
Bibliographic record
Abstract
There are three main sections that are examined in this research. The first is whether or not a porcupine quill would be a suitable model for future needle designs in order to reduce the pain of pediatric vaccination. The second section delves into whether the Biomedical Imaging and Therapy Beamline at the Canadian Light Source Synchrotron can be used to monitor the path of an injection in a live animal through imaging. The third section involves engineering designs for the Biomedical Imaging and Therapy Beamline.\nA literature review was completed which showed that porcupine quills enter human tissue with less force than is required for a typical needle. However, through in line phase contrast imaging, I was unable to conclusively show that there was less tissue damage caused by a porcupine quill than a conventional needle when it enters tissue. Based upon the literature review and the anecdotal evidence of the veterinarian performing the injections, I am able to conclude that it is possible that a metal needle modelled after a porcupine quill would damage tissue less than a standard hypodermic needle during insertion. This reduction in tissue damage could possibly reduce the pain during pediatric vaccination. A redesigned needle may also be suited for suture procedures, especially in ophthalmology, where the fine nerves around the eye are very sensitive to pain. Suture procedures do not require the needle to be pulled back against the grain and may therefore get the most benefit from the lower insertion force of the porcupine quill type needle.\nDesign and fabrication of such a needle would be the next step in possible research.\nExamining the images obtained at the Canadian Light Source, it can be concluded that the absorption, distribution, metabolism and excretion of an injected contrast agent can be monitored through imaging on the Biomedical Imaging and Therapy Beamline. This was confirmed by comparing images obtained in a traditional computed tomography scanner with the images obtained at the Canadian Light Source.\nThe engineering designs created during this research were fabricated and put into use at the Biomedical Imaging and Therapy beamline at the Canadian Light Source Synchrotron.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.012 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".