Drug release kinetics of pH‐responsive microgels of different glass‐transition temperatures
Bibliographic record
Abstract
ABSTRACT The pH‐responsive microgels (MGs) consisting of methacrylic acid‐ethyl acrylate (MAA‐EA), methacrylic acid‐butyl methacrylate (MAA‐BMA) or methacrylic acid‐methyl methacrylate (MAA‐MMA) crosslinked with di‐allyl phthalate (DAP) were synthesized via emulsion polymerization. It was found that the energy required to extract a proton from MGs with higher glass‐transition temperature ( T g ) was greater than at a lower T g . Procaine hydrochloride (PrHy) was used to study the release of a model hydrophobic drug from MGs with different T g s. A drug selective electrode (DSE) was used to monitor the release as a function of pHs and T g s. With increasing pH or decreasing T g , the swelling of MGs was enhanced, leading to greater release of the drug. From the Berens and Hopfenberg model, the contributions of chain relaxation and diffusion processes during a release process were determined. The drug release from lower T g MGs and at high pH is dominated by diffusion rather than chain relaxation. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019 , 136 , 47284.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".