Inflammation and Heart Rate–corrected QT Interval: Evidence for a Potentially Reversible Cause of Sudden Death in Patients with Rheumatoid Arthritis?
Bibliographic record
Abstract
Rheumatoid arthritis (RA) is associated with an increased cardiovascular (CV) mortality risk; however, evidence to date suggests that the presence of traditional CV risk factors, prevalent in patients with RA, only partially accounts for the increased cardiac mortality risk1. In an effort to reduce the CV morbidity and mortality associated with RA, numerous novel risk factors have been sought and implicated, including myocardial repolarization abnormalities2, autonomic dysfunction3, and inflammation4. Given that RA is associated with a doubled risk of sudden cardiac death1, an arrhythmic mechanism would seem plausible. The QT interval marks the time from onset of ventricular depolarization to the completion of repolarization and can be measured using a 12-lead electrocardiogram (ECG) from the beginning of the Q wave to the end of the T wave. Prolongation of ventricular repolarization duration increases the risk of torsade de pointes, which can lead to ventricular fibrillation and sudden death. Prolongation of heart rate-corrected QT interval (QTc) independently predicts sudden death in the general population5 and … Address correspondence to A.M. Adlan. E-mail: adlan.ahmed{at}gmail.com
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.008 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.007 | 0.005 |
| Insufficient payload (model declined to judge) | 0.004 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".