153. The Effect of Timing of Tetanus–Diphtheria and Pertussis Vaccine Administration in Pregnancy on The Avidity of Pertussis Antibodies
Bibliographic record
Abstract
Abstract Background Tetanus–diphtheria–pertussis (Tdap) vaccination in pregnancy is currently recommended in many countries. The optimal timing of pertussis immunization in pregnancy is not well established, leading to different recommendations. We aimed to determine the effect of timing of vaccination with Tdap in pregnancy on the umbilical cord avidity of antipertussis toxin (PT) immunoglobulin G (IgG). Methods Avidity of anti-PTIgG was assessed using ammonium thiocyanate (NH4SCN) at concentrations between 0.25 M (to measure low avidity antibodies) and 3 M (to measure high avidity antibodies). Anti-PT IgG levels achieved at each NH4SCN concentration were calculated. T-tests were used to compare anti-PT IgG levels between newborns of women vaccinated in early (28–32 weeks gestation) and late (33–36 weeks gestation) third trimester. Pearson correlation assessed the relationship between the timing of vaccination and anti-PT IgG levels. Results Newborns of women vaccinated with Tdap in early third trimester (n = 43) had higher anti-PT IgG levels at 1 M and 2 M NH4SCN concentrations compared with newborns of women vaccinated in late third trimester (n = 47), 2.4 international units (IU)/mL vs. 1.9 IU/mL (P = 0.0073) and 2.3 IU/mL vs. 1.7 IU/mL (P = 0.0354), respectively, after adjustment for gestational age at birth. There was a negative association between later timing of vaccination in third trimester and anti-PT IgG levels achieved at 0.5 M, 1 M, 1.5 M, and 2 M NH4SCN (all P ≤ 0.02). There was a positive association between increasing time between vaccination and delivery and anti-PT IgG levels achieved at 0.5 M, 1 M, 1.5 M, and 2 M NH4SCN (all P ≤ 0.02). Conclusion Vaccination against pertussis during early third trimester results in higher levels of high avidity antibodies compared with vaccination in late third trimester. High avidity antibodies may confer greater protection to the neonate supporting recommendations for vaccination at 28–32 WG vs. 33–36 WG. Disclosures All authors: No reported disclosures.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".