PSXII-10 Providing excess metabolizable protein prior to calving shifts the protein composition of colostrum and early post-colostrum serum proteomic profiles in neonatal beef calves.
Bibliographic record
Abstract
The effect of oversupplying metabolizable protein (MP) pre-partum on pre-partum colostrum protein composition and calf serum protein composition was determined to characterize the nutritionally modulated transfer of biomarkers from mother to calf. Thirteen primiparous crossbred Hereford cows were assigned to a high protein (HP; 133% of MP requirement, n = 6) or control (CON; 100% of predicted MP requirement, n = 7) treatment. Cows were individually fed their treatment diet from d -55 relative to parturition. Colostrum was sampled equally from all quarters and calf serum was collected prior to and 6-hours post colostrum consumption. Colostrum contained 213 distinct detectible proteins. Of these, 11 proteins showed a greater than 2 fold increase in abundance from HP cows. Three of these proteins (AMER3, G3N1Y3, G3MZ21) show 1.4–6.9 fold depletion in the serum of calves fed colostrums from HP dams. The other eight proteins did not appear in detectible levels in the calves’ serum before or after colostrum. An additional 16 proteins were reduced more than 2 fold in the colostrum from HP cows, relative to CON. A total of 179 distinct proteins were detectible in the serum sampled before and after colostrum consumption. Of these, 28 were more than 2 fold greater prevalence in the serum of HP calves. Eighteen of these proteins were detectible in colostrum, with 10 enriched up to 1.25 fold in HP colostrum, and 8 depleted down to 0.82 fold in treatment colostrum. Additionally, 19 proteins were greater than 2 fold less prevalent in the serum of calves feed colostrum from HP dams, including haptoglobin antioxidant protein and IαI-heavy-chain inflammatory regulators. Thus excess of MP promotes a shift in select proteins, including immune-regulators, in colostrum which promotes an associated shift in different factors and biomarkers in calf serum post-colostrum consumption.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".