Impact of a 6-month aerobic exercise intervention on oxidative stress in sedentary older adults
Bibliographic record
Abstract
Background: Reactive oxygen species (ROS) play integral roles in cell signalling and systemic processes and are tightly controlled through workings of antioxidants. An imbalance in this relationship can lead to oxidative stress. Completion of regular exercise can mitigate oxidative stress, strengthen antioxidant capacity and improve oxidative stress- associated conditions, such as metabolic syndrome (MetS) and decreased cerebrovascular function. However, there is limited knowledge as to how the aging population with and without MetS compare in terms of changes in markers of oxidative stress and antioxidant profiles with an aerobic exercise intervention, and the effect these changes in have on cerebrovascular function. Objective: We aimed to assess the effects of a 6-month aerobic exercise intervention on markers of oxidative stress and antioxidant capacity in older, sedentary yet healthy adults, and to determine how MetS status affected these exercise-induced changes. Further, as an exploratory measure, we aimed to assess the association between changes in markers of oxidative stress and antioxidant capacity and measures of cerebrovascular function. Design: Blood samples from 206 participants (mean age=66.8 ± SE=6.4 years, 104 females) pre-, midway, and post-intervention were assessed for markers of oxidative stress (advanced oxidation protein products [AOPP; malondialdehyde [MDA]; 3-nitrotyrosine [3-NT]) and antioxidant capacity (superoxide dismutase [SOD]; uric acid [UA]; ferric- reducing ability of ṗ lasma [FRAP]; nitric oxide metabolites [NOx]; catalase). Maximal aerobic capacity (VO2max), anthropometric and demographic information was also collected. Repeated measures linear mixed models adjusted for covariates were used to evaluate changes in markers of oxidative stress and antioxidant capacity across the exercise intervention. Factors represented by changes in markers of oxidative stress and antioxidant status were used in a linear regression analysis to assess the potential association between oxidative stress and cerebrovascular function. Results: There was a significant effect of the exercise intervention on decreasing levels of AOPP (p=0.004) however, neither MetS status (p=0.214) nor sex (p=0.437) modified the effect. Individuals with MetS had significantly higher levels of AOPP (p<0.001), MDA (p<0.001), FRAP (p=0.03) and UA (p=0.003) compared to those without. Men possessed significantly higher levels of AOPP (p=0.001), FRAP (p<0.001), catalase (p=0.013) and UA (p<0.001) compared to women. Interestingly, the effect of MetS status on FRAP and 3-NT was highly dependent on sex. Further, exercise-induced changes in measures of oxidative stress and antioxidant status were significantly associated with post-intervention measures of cerebrovascular function at rest and submaximal exercise. Conclusion: These results indicate that MetS may blunt exercise-induced improvements in oxidative stress and that changes in markers of oxidative stress and antioxidant status may impact exercise-induced cerebrovascular improvements in older, healthy adults.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".