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Record W2904490999 · doi:10.1093/jas/sky404.259

310 What’s Next for Genomic Selection in Dairy Cattle?.

2018· article· en· W2904490999 on OpenAlexaboutno aff
Michael Lohuis

Bibliographic record

VenueJournal of Animal Science · 2018
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGenetic and phenotypic traits in livestock
Canadian institutionsnot available
Fundersnot available
KeywordsHeritabilityGenomic selectionInbreedingBiologySelection (genetic algorithm)Genetic gainGenotypingBiotechnologyDairy cattleGeneticsComputational biologyPopulationGenetic variationGeneComputer scienceGenotypeMedicineSingle-nucleotide polymorphism

Abstract

fetched live from OpenAlex

Genomic selection has transformed dairy genetic improvement from progeny testing to genomic testing. In Canada, genetic improvement rates have increased 2 to 3-fold due to improvements in generation interval and selection intensity. In some cases, unfavorable genetic trends in low heritability traits such as female fertility and disease tolerance have been reversed. Unfortunately, rates of inbreeding have accelerated due to rapid generational turnover. Currently, genome-tested young bull use has reached 70% and continues to rise. Due to intense preselection of bull parents the potential for bias in genomic prediction is increasing. Furthermore, as modern dairy farms withdraw from milk-recording programs and focus on in-house data collection and management tools, there is a risk that accuracy of genomic predictions could decrease over time. To compensate, more emphasis will be needed on genotyping and phenotyping unselected reference populations to maintain genomic evaluation accuracy and unbiasedness. Fortunately, traits that were previously too expensive, difficult or time-consuming to phenotype, may now be feasible in focused reference populations. AI companies may need to help support reference populations to maintain the integrity of conventional dairy traits but may also gain data on valuable novel traits such as feed efficiency, disease resistance and heat tolerance. New genomic analysis methods and technologies are helping scientists to better understand gene function. It has been shown such information can be incorporated into genomic evaluation to increase accuracy of predictions substantially and to reduce the risk of deleterious/lethal genes to be passed to the next generation. Previously, the infinitesimal model or “black box” approach was the preferred model for selection; however, genomic analysis tools may help breeders better understand the underlying genetic architecture of traits and incorporate this information into breeding programs. Additionally, opportunities exist to improve evaluation models to account for allelic effects and interactions.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.009
metaresearch head score (Gemma)0.007
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Theoretical or conceptual · Consensus signal: none
GenreCandidate signal: Commentary · Consensus signal: Commentary
Teacher disagreement score0.010
Threshold uncertainty score0.048

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0090.007
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0010.001
Science and technology studies0.0010.004
Scholarly communication0.0030.005
Open science0.0020.001
Research integrity0.0030.004
Insufficient payload (model declined to judge)0.0090.002

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.020
GPT teacher head0.284
Teacher spread0.264 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designTheoretical or conceptual
Domainnot available
GenreCommentary

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2018
Admission routes1
Has abstractyes

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