MétaCan
Menu
Back to cohort
Record W2904827603 · doi:10.1038/s41385-018-0114-4

Age-of-diagnosis dependent ileal immune intensification and reduced alpha-defensin in older versus younger pediatric Crohn Disease patients despite already established dysbiosis

2018· article· en· W2904827603 on OpenAlex
Yael Haberman, Melanie Schirmer, Phillip J. Dexheimer, Rebekah Karns, Tzipi Braun, Mi‐Ok Kim, Thomas D. Walters, Robert N. Baldassano, Joshua D. Noe, Joel R. Rosh, James Markowitz, Wallace Crandall, David Mack, Anne M. Griffiths, Melvin B. Heyman, Susan S. Baker, Richárd Kellermayer, Dedrick E. Moulton, Ashish Patel, Ajay Gulati, Steven J. Steiner, Neal S. LeLeiko, Anthony Otley, Maria Oliva‐Hemker, David Ziring, Barbara S. Kirschner, David J. Keljo, Stephen L. Guthery, Stanley A. Cohen, Scott B. Snapper, Jonathan Evans, Marla Dubinsky, Bruce J. Aronow, Jeffrey S. Hyams, Subra Kugathasan, Curtis Huttenhower, Ramnik J. Xavier, Lee A. Denson

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueMucosal Immunology · 2018
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicInflammatory Bowel Disease
Canadian institutionsIzaak Walton Killam Health CentreChildren's Hospital of Eastern OntarioUniversity of OttawaHospital for Sick ChildrenSickKids FoundationUniversity of Toronto
FundersNational Institute of Diabetes and Digestive and Kidney DiseasesCrohn's and Colitis FoundationNational Institute of Dental and Craniofacial ResearchIsraeli Centers for Research ExcellenceIsrael Science FoundationCincinnati Children's Hospital Medical CenterNational Institutes of HealthLeona M. and Harry B. Helmsley Charitable Trust
KeywordsImmunologyAntimicrobial peptidesLachnospiraceaeDysbiosisImmune systemCrohn's diseaseBiologyDiseaseDefensinPathogenesisMedicineInternal medicineAntimicrobialGut floraGeneMicrobiologyGenetics

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.168
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.010
GPT teacher head0.241
Teacher spread0.231 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it