Coarctation of the aorta and the nature of collateral circulation
Bibliographic record
Abstract
Coarctation of the aorta (CoA) is typically diagnosed during childhood; however, a small proportion of patients present for the first time in adulthood. When left untreated, survival beyond the age of 50 years is rare.1Baumgartner H. Bonhoeffer P. De Groot N.M. de Haan F. Deanfield J.E. Galie N. et al.ESC guidelines for the management of grown-up congenital heart disease (new version 2010).Eur Heart J. 2010; 31: 2915-2957Crossref PubMed Scopus (1870) Google Scholar, 2Silversides C.K. Kiess M. Beauchesne L. Bradley T. Connelly M. Niwa K. et al.Canadian Cardiovascular Society 2009 Consensus Conference on the management of adults with congenital heart disease: outflow tract obstruction, coarctation of the aorta, tetralogy of Fallot, Ebstein anomaly, and Marfan's syndrome.Can J Cardiol. 2010; 26: e80-e97Abstract Full Text PDF PubMed Scopus (166) Google Scholar Older patients with CoA are at a higher risk of major complications, such as aortic dissection and rupture, and these lesions generally require repair (open or endovascular surgery).3Jurcut R. Daraban A.M. Lorber A. Deleanu D. Amzulescu M.S. Zara C. et al.Coarctation of the aorta in adults: what is the best treatment? Case report and literature review.J Med Life. 2011; 4: 189-195PubMed Google Scholar, 4Forbes T.J. Moore P. Pedra C.A. Zahn E.M. Nykanen D. Amin Z. et al.Intermediate follow-up following intravascular stenting for treatment of coarctation of the aorta.Catheter Cardiovasc Interv. 2007; 70: 569-577Crossref PubMed Scopus (142) Google Scholar, 5Chessa M. Carrozza M. Butera G. Piazza L. Negura D.G. Bussadori C. et al.Results and mid-long-term follow-up of stent implantation for native and recurrent coarctation of the aorta.Eur Heart J. 2005; 26: 2728-2732Crossref PubMed Scopus (149) Google Scholar, 6Golden A.B. Hellenbrand W.E. Coarctation of the aorta: stenting in children and adults.Catheter Cardiovasc Interv. 2007; 69: 289-299Crossref PubMed Scopus (111) Google Scholar Here we describe a case of a 49-year-old man with a history of smoking and hypertension (taking two antihypertensive drugs) who presented with calf claudication for 300 meters after years of evolution. He had no other symptoms, such as resting pain or trophic lesions. Moreover, he had a history of ischemic stroke in the territory of the right middle cerebral artery, with no sequelae. At physical examination, the bilateral upper limb pulses were broad and symmetric, whereas the lower limb pulse amplitude was decreased. He had a vascular murmur in the back but did not display any alterations in pulmonary auscultation. On echocardiography, mild aortic and mitral regurgitation with biatrial dilation was discovered. The Doppler examination showed a pressure gradient between the arms and legs of 42 mm Hg and an ankle-brachial index of 0.7 on the left and 0.69 on the right. Computed tomography angiography revealed an extensive collateral circulation (A) bypassing the isthmus CoA (B). In this case, the collateral vessels that allowed the flow of blood from high-to low-pressure areas were internal thoracic arteries, both to epigastric vessels and intercostal arteries; subclavian arteries through thoracoacromial to intercostal arteries; thyrocervical trunks through descending scapular arteries to intercostal arteries and through vertebral and anterior spinal arteries. Because the patient met the criteria for surgical treatment1Baumgartner H. Bonhoeffer P. De Groot N.M. de Haan F. Deanfield J.E. Galie N. et al.ESC guidelines for the management of grown-up congenital heart disease (new version 2010).Eur Heart J. 2010; 31: 2915-2957Crossref PubMed Scopus (1870) Google Scholar (open or endovascular), the interventional cardiologist attempted to recanalize and stent the coarctation without success. Thus, he was guided to vascular surgery. This patient will be treated conventionally in collaboration with cardiothoracic surgery. This patient consented to the publication of this article.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".