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Record W2907587370 · doi:10.14258/jcprm.2018043883

THE STUDY OF THE FLAVONOIDS AND ANTIDEPRESSANT ACTIVITY OF THE LEAVES AND LIQUID EX-TRACT OF CRATAEGUS SUBMOLLIS

2018· article· en· W2907587370 on OpenAlexaboutno aff
В. А. Куркин, Елена Николаевна Зайцева, Татьяна Владимировна Морозова, О. Е. Правдивцева, Е. В. Авдеева, А. В. Куркина, Albert I. Agapov

Bibliographic record

Venuechemistry of plant raw material · 2018
Typearticle
Languageen
FieldAgricultural and Biological Sciences
TopicBotanical Studies and Applications
Canadian institutionsnot available
Fundersnot available
KeywordsCrataegusAntidepressantTraditional medicineMedicineChemistryPharmacologyPsychiatry

Abstract

fetched live from OpenAlex

Nowadays flowers and fruits of various types of hawthorn are widely used as cardiotonic drugs in Russian Federation. In our opinion a promising species for harvesting raw materials is Quebec hawthorn (Crataegus submollis Sarg., Rosaceae). Quebec hawthorn is successfully cultivated on the territory of the Russian Federation and is characterized by rapid growth and high yield in comparison with wild species. An additional point is that one of the possible types of raw materials are hawthorn leaves widely used abroad. Quebec hawthorn leaves contain flavonoids, among which there is a hyperoside. The maximum of the absorption curve of the extract solution of Quebec hawthorn leaves with an aluminum chloride solution of 412 nm. We have developed a quantification method for determination the total flavonoids in the Quebec hawthorn leaves calculated as hyperoside. It was established that the optimum extraction solvent for this raw material is 70% ethanol. The level of content and dynamics of accumulation of the total flavonoids in the Quebec hawthorn leaves during the growing season of 2017 was studied. The maximum content of total flavonoids in the Quebec hawthorn leaves (3.12 ± 0.05% calculated on hyperoside) is observed in May, during plant flowering. The liquid extract based on Quebec hawthorn leaves possesses moderate antidepressant activity. For this reason, leaves of Quebec hawthorn leaves are promising medicinal plant raw materials.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.035
Threshold uncertainty score0.070

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.011
GPT teacher head0.206
Teacher spread0.195 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations6
Published2018
Admission routes1
Has abstractyes

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