Early-Life Triclosan Exposure and Behavior Problems in 8-Year-Old Children
Bibliographic record
Abstract
Background: Triclosan may decrease circulating thyroxine levels or interfere with thyroid hormone signaling to adversely affect neurodevelopment. However, we are unaware of studies examining associations between triclosan exposure and childhood behavior problems.Methods: We used data from mother-child pairs enrolled in a Cincinnati, OH pregnancy and birth cohort study between 2003-2006 (The HOME Study). In 202 mother-child pairs, we quantified urinary triclosan concentrations in up to 3 maternal samples collected between 2nd trimester of the pregnancy and delivery, and in up to 6 child samples between ages 1 and 8 years. Caregivers rated their children’s behavior at age 8 years using the Behavioral Assessment System for Children-2. We used a two-stage model to estimate changes in behavior problem scores with a 10-fold increase in mean gestational or childhood triclosan concentrations, accounting for triclosan exposure measurement error.Results: Gestational triclosan was positively associated with externalizing problem scores and some related clinical subscales; these associations were stronger in boys than girls (triclosan x sex interaction p-values < 0.2). Specifically, each 10-fold increase in gestational triclosan was associated with higher externalizing (β: 5.0; 95% CI: 1.1-8.9), attention (β: 6.4; 95% CI: 2.2-11), and hyperactivity (β: 6.4; 95% CI: 2.2-11) scores in boys. We observed a similar pattern of associations of childhood triclosan with externalizing and related clinical subscales, but these associations were substantially attenuated after we adjusted for gestational triclosan. In contrast, associations between gestational triclosan and behavior problems were slightly attenuated. In general, triclosan concentrations were not associated with internalizing problems.Conclusion: In this cohort, gestational urinary triclosan concentrations were associated with more externalizing, inattention, and hyperactivity behaviors at age 8 years in boys, but not girls.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".