<i>PROAFTN</i> Classifier for Feature Selection with Application to Alzheimer Metabolomics Data Analysis
Bibliographic record
Abstract
Early and accurate Alzheimer’s disease (AD) diagnosis remains a challenge. Recently, increasing efforts have been focused towards utilization of metabolomics data for the discovery of biomarkers for screening and diagnosis of AD. Several machine learning approaches were explored for classifying the blood metabolomics profiles of cognitively healthy and AD patients. Differentiation between AD, mild cognitive impairment (MCI) and cognitively healthy subjects remains difficult. In this paper, we propose a new machine learning approach for the selection of a subset of features that provide an improvement in classification rates between these three levels of cognitive disorders. Our experimental results demonstrate that utilization of these selected metabolic markers improves the performance of several classifiers in comparison to the classification accuracy obtained for the complete metabolomics dataset. The obtained results indicate that our algorithms are effective in discovering a panel of biomarkers of AD and MCI from metabolomics data suggesting the possibility to develop a noninvasive blood diagnostic technique of AD and MCI.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".