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Record W2912487578 · doi:10.1126/sciimmunol.aau8125

Association of HLA-dependent islet autoimmunity with systemic antibody responses to intestinal commensal bacteria in children

2019· article· en· W2912487578 on OpenAlexafffund
Alexandra Paun, Christopher Yau, Shahab Meshkibaf, Michelle C. Daigneault, Leili Marandi, Steven Mortin-Toth, Amit Bar‐Or, Emma Allen‐Vercoe, Philippe Poussier, Jayne S. Danska

Bibliographic record

VenueScience Immunology · 2019
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicDiabetes and associated disorders
Canadian institutionsMcGill UniversityHospital for Sick ChildrenUniversity of GuelphUniversity of TorontoMontreal Neurological Institute and HospitalSunnybrook Hospital
FundersBreakthrough T1D CanadaCanadian Institutes of Health ResearchHospital for Sick ChildrenJuvenile Diabetes Research Foundation United KingdomNational Institute of Diabetes and Digestive and Kidney DiseasesJuvenile Diabetes Research Foundation Canada
KeywordsAutoimmunityCommensalismImmunologyBiologyAntibodyIsletHuman leukocyte antigenImmune systemBacteriaAntigenDiabetes mellitusGenetics

Abstract

fetched live from OpenAlex

genotype and islet autoantibody specificity and with a future diagnosis of T1D. Further, we present a platform to investigate antibacterial antibodies in biological fluids that is applicable to studies of autoimmune diseases and responses to therapeutic interventions.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.003
Threshold uncertainty score0.010

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.001
Science and technology studies0.0000.001
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0030.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.003
GPT teacher head0.239
Teacher spread0.235 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations59
Published2019
Admission routes2
Has abstractyes

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