Abstract 15658: Arginine-vasopressin Levels Are Increased in Heart Failure With Preserved Ejection Fraction and Correlate With LV Hypertrophy
Bibliographic record
Abstract
Abstract: Arginine-Vasopressin (AVP) exerts a variety of effects. in addition to its antidiuretic effect via V2 receptors in the kidneys, AVP has vasoconstrictive effects via its action on V1a receptors in the peripheral vasculature. Whether patients with heart failure and preserved ejection fraction (HFpEF) demonstrate increased levels of AVP, and whether this relates to left ventricular remodeling is unknown. Methods: We studied 26 subjects with heart failure and reduced ejection fraction (HFrEF), 28 subjects with HFpEF, and 95 control subjects without heart failure. AVP was measured ELISA (Cayman Chemicals ; USA). In a subgroup of subjects (n=110) we measured LV mass with magnetic resonance imaging (SSFP cine sequences), with LV segmentation using CMR42 (Circle CV Imaging; Calgary, Canada). Results: AVP levels were significantly greater in HFpEF (1.01; 95%CI=0.84 to 1.19)Compared to either HFrEF (0.72; 95%CI=0.58 to 0.87) or controls without HF (0.69; 95%CI=0.62 to 0.75; ANOVA P<0.0001). After adjustme...
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".