Cfp1/Cps40 stabilizes MLL complex formation through multi-valent interactions
Bibliographic record
Abstract
The SET1 family of methyltransferases (SET1A/B, MLL1-4) are responsible for the methylation of Lys-4 on histone H3 (H3K4), a post-translational modification that is predominantly localized in the promoter and enhancer regions of actively transcribed genes. Moreover, mis-regulation or mutations of members of SET1 family of PKMTs is now recognized as a hallmark of cancers. Members of the SET1 family of methyltransferases require several regulatory subunits to efficiently methylate histone H3. These subunits include DPY30/Cps25, WDR82/Cps30, WDR5/Cps35, Cfp1/Cps40, RbBP5/Cps50 and Ash2L/Cps60. Once bound to SET1, these proteins form a protein complex referred to as COMPlex ASsociated to SET1 (COMPASS) whose role is to fully activate the methyltransferase activity of SET1. While previous structural studies highlighted important molecular underpinnings underlying the interaction of COMPASS subunits 1-3 , they failed to capture the overall architecture of COMPASS. In addition, owing to the low resolution of a Cryo-EM structure of COMPASS 4 , an in-depth understanding of the structural determinants controlling the formation and regulation of COMPASS remains elusive.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.004 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".