Photocatalytic Degradation of 2, 4-D and Transition of Endocrine Disruptive Activity Using Transcriptome Based Bioassay in Zebrafish Embryos
Bibliographic record
Abstract
2, 4-Dichlorophenoxyacetic acid (2, 4-D) is one of the most widely used halogenated agricultural chemicals around the world and a well known endocrine disrupting chemical (EDC).TiO 2 based photocatalytic degradation of 2, 4-D was carried out and residual endocrine disruptive (ED) activity was determined by an in vivo model of zebrafish embryos exposed to various concentrations of 2, 4-D and its degraded products from 5 hpf (hours post fertilization) to 72 hpf.Quantitative Real Time PCR was carried out to determine the relative expression of Heat shock protein (HSP70) and Glutathione peroxidase (GPX) genes of zebrafish using ß-actin as housekeeping gene.HSP 70 expression increased at 150 µg/L 2, 4-D concentration while the expression was significantly lowered after its photocatalytic degradation.GPX expression was not significantly altered.The results reveal the validity of HSP gene affected by 2, 4-D exposure and some probability of toxic potential of byproducts formed during its degradation.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".