Photocatalytic Degradation of 2, 4-D and Transition of Endocrine Disruptive Activity Using Transcriptome Based Bioassay in Zebrafish Embryos
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
2, 4-Dichlorophenoxyacetic acid (2, 4-D) is one of the most widely used halogenated agricultural chemicals around the world and a well known endocrine disrupting chemical (EDC).TiO 2 based photocatalytic degradation of 2, 4-D was carried out and residual endocrine disruptive (ED) activity was determined by an in vivo model of zebrafish embryos exposed to various concentrations of 2, 4-D and its degraded products from 5 hpf (hours post fertilization) to 72 hpf.Quantitative Real Time PCR was carried out to determine the relative expression of Heat shock protein (HSP70) and Glutathione peroxidase (GPX) genes of zebrafish using ß-actin as housekeeping gene.HSP 70 expression increased at 150 µg/L 2, 4-D concentration while the expression was significantly lowered after its photocatalytic degradation.GPX expression was not significantly altered.The results reveal the validity of HSP gene affected by 2, 4-D exposure and some probability of toxic potential of byproducts formed during its degradation.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it