Bibliographic record
Abstract
ABSTRACT Heparin-induced thrombocytopenia is the most common immune-mediated adverse drug reaction, occurring in 1 % to 3% of postoperative patients receiving unfractionated heparin prophylaxis for 7 to 14 days. Approximately 1 in 100 patients receiving a therapeutic dose of unfractionated heparin for a week or more will experience thrombosis related to heparin-induced thrombocytopenia. Heparin-induced thrombocytopenia is characterized by activation of coagulation and platelets. Diagnosis of the condition should take into account the timing of the thrombocytopenia (which typically occurs on day 5 to 10 after initiation of heparin), the degree of the thrombocytopenia, and the presence of new thrombosis. Use of warfarin alone to treat acute heparin-induced thrombocytopenia complicated by deep venous thrombosis sometimes results in loss of a limb because of venous limb gangrene, probably because warfarin can cause severe reduction in protein C without a simultaneous reduction in the generation of thrombin in these patients. New treatments now available in Canada to reduce thrombin generation in heparin-induced thrombocytopenia (such as danaparoid and lepirudin) are useful in managing the thrombotic consequences of heparin-induced thrombocytopenia. RESUME La thrombocytopenie d'origine heparinique represente la reaction indesirable d'origine immunologique la plus courante. En effet, elle survient chez 1 % a 3 % des patients qui recoivent un traitement prophylactique post-operatoire a l'heparine non fractionnee durant 7 a 14 jours. Environ 1 patient sur 100 qui recoivent une dose therapeutique d'heparine non fractionnee pendant une semaine ou plus souffrira de thrombose associee a une thrombocytopenie d'origine heparinique. La thrombocytopenie d'origine heparinique est caracterisee par l'activation de la coagulation et des plaquettes. Le diagnostic de cette affection devrait tenir compte du moment auquel survient la thrombocytopenie (cette derniere survenant habituellement entre le cinquieme et le dixieme jour apres le debut de l'heparinotherapie), du degre de la thrombocytopenie et de la presence de nouveaux thrombi. Le recours a la warfarine seule pour traiter une thrombocytopenie aigue d'origine heparinique compliquee par une thrombose veineuse profonde peut entrainer quelques fois la perte d'un membre a cause d'une gangrene veineuse du membre, probablement parce que la warfarine cause une diminution prononcee du taux de proteine C sans reduction simultanee du taux de thrombine chez ces patients. Les nouveaux traitements maintenant offerts au Canada pour reduire la production de thrombine dans les cas de thrombocytopenie d'origine heparinique (comme le danaparoicle et la lepirudine) sont utiles dans le traitement des consequences thrombotiques de la thrombocytopenie d'origine heparinique.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.014 | 0.004 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".