← Back to cohort
Intensive blood pressure reduction with intravenous thrombolysis therapy for acute ischaemic stroke (ENCHANTED): an international, randomised, open-label, blinded-endpoint, phase 3 trial
Yining Huang, Richard I. Lindley, Xiaoying Chen, Hisatomi Arima, Guofang Chen, Qiang Li, Laurent Billot, Candice Delcourt, Philip M. Bath, Joseph P. Broderick, Andrew M. Demchuk, Geoffrey A. Donnan, Alice C. Durham, Pablo M. Lavados, Tsong-Hai Lee, Christopher Levi, Sheila Cristina Ouriques Martins, Verónica V. Olavarría, Jeyaraj Pandian, Mark Parsons, Octávio Marques Pontes‐Neto, Stefano Ricci, Shoichiro Sato, Vijay K. Sharma, Federico Silva, Lili Song, Joanna M. Wardlaw, Ji-Guang Wang, Xia Wang, Mark Woodward, Thompson Robinson, Craig S. Anderson, Tsong‐Hai Lee, Ji‐Guang Wang, Jong S. Kim, Christian Stapf, R. J. Simes, Graeme J. Hankey, Peter Sandercock, Marie‐Germaine Bousser, Ka Sing Wong, Anish Scaria, Yoichiro Hirakawa, Tom J. Moullaali, Cheryl Carcel, Sully X. Fuentes-Patarroyo, Dino Benito, Yongjun Cao, Amy Kunchok, Stephen L. Winters, Shelagh B. Coutts, Sohei Yoshimura, Shoujiang You, Jie Yang, Guojun Wu, Shihong Zhang, Lisa Manning, Amit Mistri, Victoria J. Haunton, Jatinder S. Minhas, Alejandra Malavera, Joyce Lim, Leibo Liu, Namrata N. Kumar, Nicole Tay, Kerry Jenson, Sarah Richtering, Sharon Tucker, Elizabeth Knight, Elizaveta Ivanova, Emma Thembani, E. Odgers, Elizabeth A. Sanders, Sabrina Small, Ruchita Vaghasiya, Manuela Armenis, Paul S. Donnelly, Merza Ahmad Baig, N. J. Blacklock, B. Naidu, Helen Monaghan, Phillipa Smith, Parisa Glass, Xuejie Bai, Qiancheng Li, Pingping Zhu, Liang Kong, Ruihong He, He Zhao, Jiajie Lv, Haijing Jia, Zhen Xi, Yuhan Cong, Buliang Cui, Hua Deng, Ying Guo, Lingyu He, Ruolan Jia, Nan Li, Wei Li, Mengxiao Liu, Meng Zhang, Ziwei Xu, Ting Zhang, Yan Zhao, Philip D. Gregory, Yunjeong In, Su Kim, Jung Eun Ahn, Sul Hwa Kim, Young Lan Hong, Francisca González-McCawley, Magda Carla Ouriques Martins, Bernardita Portales, Ching‐Yi Wang, S J Ryu, Hardeep Aujla, Sue Lewin, Tracy Kumar, Sara Barrows, Ahtasam Ebraimo, Hong Ha Uyen, Nguyen Anh Giang, Le Thi My Linh, Lê Thị Thuý An, Do Minh Phuong, Pham Vu Bich Ngoc, Nguyen Mai Hang, Nguyen Thi Bich Tran, Ha Thi Thu Hien, Mai Bao Yen, Ngo Thuy Tram, Tran Thi Thanh Truc, Nguyen A. Hoa, Nguyen T.B. Thuan, HTK Oanh, Deepti Arora, Shweta Jain Verma, Martín Krause, Miriam Priglinger, Susan Day, S. Jala, Lucy Davies, Emma Ray, Sherisse Celestino, Linda Law, Tissa Wijeratne, G. André Ng, Ken Nagao, Gary Weiss, N.F. Titton, C. Batista, Leonardo Augusto Carbonera, Ricardo Lessa de Castro, R.K. Martins Filho, Milena C Libardi, Gustavo Miranda Martins, D. Leite Fagundes, Gabriel Baron, Andrew Boehringer, Rodrigo Bazán, Geórgia de Carvalho Braga, Gustavo José Luvizutto, Priscila Watson Ribeiro, Fernanda Cristina Winckler, Carla Heloísa Cabral Moro, Alexandre Luiz Longo, R. Liberato, Roberto Ramos Barbosa, Pedro Magalhães, M. Portal, Kevin Martin, Andressa de Souza, Daissy Liliana Mora Cuervo, Daniel Perin, Lucas Miranda Marques, Fernanda Oliveira, Marco Battaglini, F. Lourenço, G. Silva, Luís Duarte, Marta Alves, João Carlos Sousa, M. Uhehara, Alejandro M. Brunser, Enrico Mazzon, M. Spencer, Indrani Acosta, A. Rojo, R. Rivas, C Klapp, L. Carvallo, P. Carvallo, Eloy Mansilla, J. Flores, M. Alvarado, Alex F. Herrera, Carolina Reyes, F. Jurado, G. Bustamante, Laura Bravo, José Manuel Matamala, Rodrigo Guerrero, Shuyu Zhou, Ping Li, Wei Liu, L. Liu, Yaohua Tian, Huiling Xu, Jing Wang, Lingling Wang, Min Yan, Lei Wang, Qilu Zhang, Chao Liu, Jie Shi, Xiaoyi Zhang, L. Tai, Lei Xu, Lu Hua, Xianchan Li, Junshan Zhou, Y. Liu, Ping Gong, H. Zhao, Jinli Zhang, Ruikun Li, Q. Chen, Yan Li, Longfei Wu, Lijun Jia, Xiaonan Guo, Guofeng Chen, Binshan Lin, Wusheng Zhu, Kun Yang, Zheng Zhang, Chenglong Xie, Dawei Wu, Yi Wang, D. Liu, Z. Liu, Liming Liang, Qi Cao, Jun Xia, Yiyun Weng, Jianping Li, Tian Xu, Deqin Geng, Xiuli Yan, D. Wang, Naisi Zhao, Jianping Li, Z. Tang, Weihua Yin, Shuguang Wang, Wei Huang, Yuan‐Han Yang, Anna Song, Yonggang Hao, A. Zhang, B. Qiao, H. Yan, H. Liu, Ying Lv, Heping Yang, Lijuan Han, Xueting Mao, Lijun Ge, Shulin He, Jian Jiang, Wen‐Chuan Wu, Hui Wang, Yujie Tang, Hongbin Sun, F. Li, Gang Li, Yirui Sun, Hongjian Zhang, Yu‐Peng Wu, Li-Ting Huang, Cong Geng, Zhengming Jin, Jianbing Zhu, F. Zhang, Rongqin Zheng, Hui Shen, Fang Liu, C. Chen, Shaoliang Chen, L. Zhou, Bo Hu, Zhenhong Zou, Jufen Liu, Xiangpeng Chang, S. Zhang, Qiu-Sha Huang, X. Liu, Sheng Liu, Wei He, Jun Feng, Li Li, Xincun Zhuang, Wen Zheng, Ying‐Ju Lai, Yu Zhou, Hongfei Duan, Qi Cao, Qinhe Yang, Juan Du, En Xu, Liying Zhan, Jason Wu, Chenchen Wei, Jianbo He, B. Wang, W Li, P. Chen, Fengmei Guo, Haijiang Dai, Min Dai, Xueliang Zeng, Bin Chen, F. Long, Q. Su, Bo‐Ying Bao, Tao Wu, Xintong Wu, Yuanhua Shao, Shun Li, Yi Xu, Jason Castellanos, M. Muñoz-Collazos, E. Solano, W.H.T. Leung, S. Sureshbabu, Sanjeev Sharma, Sarah George, Shashank Shekhar, S.K. Singla, Lokesh Saini, SUNITA SUNITA, Mahesh Kate, R. Sarvotham, Akanksha Grace William, Mohanti Bk, R. Benny, Vyankatesh Bolegave, M.F. Baslé, Stephen Gore, Pravin George, S. Kumaravelu, S. Rahamath, Preeti Raj, Akella Radha Rama Devi, Arvind Sharma, Jayesh Prajapati, Mahesh Parmar, Darshan Patel, Terry Panchal, Sankar Prasad Gorthi, Varun V. Prabhu, Arvind Prabhu, V. Chandran, Anjan Chatterjee, Radhika Nair, Vivek Nambiar, D. TS, T P Sreekrishnan, VAmrutha Ajai, Sonal Paul, D. Chittibabu, Nomal Chandra Borah, M. Ghose, Nusrat Choudhury, P. Gohain, K. Kalita, D. Duberkar, Nisha Pawar, R. Bhaviskar, E. Caterbi, Silvia Cenciarelli, R Condurso, E. Gallinella, Laura Greco, Cindy Marando, S. Mastrocola, A. Mattioni, Elisa Sacchini, I. Sicilia, Andrea Gallina, David Giannandrea, E Marsili, Tatiana Mazzoli, Chiara Padiglioni, Francesco Corea, Arianna Guidubaldi, Sara Micheli, Mali Barbi, Jang‐Hee Kim, Hee‐Jung Song, Hayeong Jeong, Johnny Lim, Sang‐Min Park, K.B. Lee, H.W. Hwang, Seong Uk Kwon, Dong‐Wha Kang, Young Jin Kim, Beom Joon Kim, J.M. Park, Kristan Kang, Ohseong Kwon, Young Woo Kim, J.J. Lee, Yang‐Ha Hwang, Hyuksool Kwon, Jaseong Koo, Kyoung Bun Lee, Anna Ahn, Joung‐Ho Rha, H.K. Park, C.W. Yoon, Bernard P.L. Chan, Hock‐Luen Teoh, Prakash Paliwal, L.Y.J. Wong, J.T. Chen, Deidre Anne De Silva, H.M. Chang, Natasha L. Fabiaña, Josep Martí, Rafaël Delgado, Alicia Martínez, Laura Trafí i Prats, Pelayo Camps, Chia‐Wei Liou, Thean Yen Tan, Chuanfu Liu, Henry Cheng, Helen L. Po, Yufeng Lin, Chieh Chou, Chun-Hsien Lin, C. C. Yen, Yu‐Tzu Chang, Yueh‐Han Hsu, Joshua D. Lee, Meng Lee, Yuwen Huang, Chun‐Yu Wu, Nijasri C. Suwanwela, Aurauma Chutinet, Yuttachai Likitjaroen, Duangnapa Roongpiboonsopit, S. Charnwut, Alexander Dyker, Mohammad Zakir Hossain, Girish Muddegowda, R. Sanyal, Christine Roffe, Indira Natarajan, K. Finney, L. Sztriha, James Teo, Francis K.L. Chan, Belinda Chitando, Brian Clarke, Bhakti K. Patel, Usman Khan, Rita Ghatala, Sarah Trippier, Lalit Kalra, Dulka Manawadu, Nyma Sikondari, J Aeron‐Thomas, W Sunman, Gail M. Wilkes, Caroline R. Richardson, A. Buch, J. Brooks Jackson, Omid Halse, Sheila Mashate, Peter Wilding, Thi Van Anh Nguyen, M.R. Qadiri, K. Rashed, C Buckley, Craig J. Smith, Martin James, Sharon Keenan, A. Bouring, Timothy J. England, Richard Donnelly, Jon Scott, M. Maddula, J. Beavan, Richard Perry, Nadia Francia, C. Watchhurst, A. Banaras, Amy Ashton, K. Musarrat, D. Eveson, J. Kallingal, J. M. Perez, Linda Harrison, Tracy Marsden, Jacqueline Furnace, Robert Clarke, Joanne Reid, Elizabeth A. Warburton, M.J. Macleod, Jennifer Mitchell, Diana J. Day, Nicholas Church, Edward S. Amis, Christopher Price, Helen Rodgers, R.L. Whiting, Murtaza Hussain, Mark Harvey, Simon G.A. Brown, Jayne Foot, Dinesh Tryambake, David Broughton, Ann M. Bergin, Al. Annamalai, Luke Dixon, N. Weir, Christian U. Blank, K. Harkness, A. Ali, Elaine M. Richards, Karen Stocks, David Bruce, Mushtaq Ahmad Wani, Tal Anjum, Manju Krishnan, T. Nguyen Huy, A. Truong Le Tuan, Luis Cam, Binh-Thanh Nguyen, A. Nguyen Dat, C. Nguyen Van, T. Mai Duy, P. Dao Viet, Deborah Tien, T. Vo Van, Kyuseok Kim, T. Bui Ngoc, T. Tran Le Thanh, S. Nguyen Hoanh, S. Pham Phuoc, T. Tran Van, Bùi Thị, M. Nguyen Duy, D. Ngo Van
Bibliographic record
VenueThe Lancet · 2019
Typearticle
Languageen
FieldMedicine
TopicAcute Ischemic Stroke Management
Canadian institutionsUniversity of Calgary
FundersStroke AssociationMedical Research CouncilNational Institute for Health and Care Research
KeywordsMedicineBlood pressureModified Rankin ScaleStroke (engine)ThrombolysisClinical endpointContraindicationInternal medicineClinical trialSurgeryAnesthesiaMyocardial infarctionIschemiaIschemic stroke
Abstract
No abstract in any covered source. Its absence is recorded, not treated as a negative.
No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Randomized trial · Consensus signal: Randomized trial
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.059
Threshold uncertainty score0.717
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
Opus teacher head0.053
GPT teacher head0.359
Teacher spread0.307 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
The models applied no category: nothing in the taxonomy fit this work.
Study designRandomized trial
Domainnot available
GenreEmpirical
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".
Quick stats
Citations271
Published2019
Admission routes1
Has abstractno