P603 Paediatric onset inflammatory bowel disease is not associated with more disability compared with adult onset disease
Bibliographic record
Abstract
A diagnosis of inflammatory bowel disease (IBD) during the paediatric years, may result in a larger burden of disability given that disease onset is coinciding with critical periods for physical and psychosocial development. The Inflammatory Bowel Disease Disability Index (IBD-DI) has recently been developed and validated to assess disability in patients with IBD. Our aims were to assess the burden of disability in paediatric onset as compared with adult onset disease using this index. The IBD-DI was administered to a cohort of adult patients with either paediatric or adult onset IBD, matched by duration of disease at the University of Calgary. Sociodemographic and clinical parameters including measures of disease activity, the Harvey–Bradshaw Index (HBI) for Crohn’s disease (CD) and Partial Mayo Score (PM) for ulcerative colitis (UC), were collected from participants as well as database review. A quantitative IBD-DI score was computed, based on a previously validated method.1 IBD-DI scores were compared between groups and bivariate analysis of variance was used to identify factors associated with disability level. 200 patients (101 paediatric onset, 99 adult onset) were recruited. The distributions in IBD-DI scores did not differ significantly between adult onset and paediatric onset disease (25.18 ± 13.98 vs. 22.16 ± 13.91, p = 0.13) (Figure 1) Figure 1. Distribution in Inflammatory Bowel Disease Disability Index (IBD-DI) scores between paediatric and adult onset IBD. There were also no significant differences in scores between Crohn’s disease and ulcerative colitis in adult onset (26.14 ± 13.98 vs. 22.62 ± 13.93, p = 0.27) and paediatric onset disease (22.35 ± 13.77 vs. 21.67 ± 14.50, p = 0.83), respectively. Age>25 years (p = 0.02), female gender (p = 0.04), active smokers (p =0.03) and clinically active disease (p < 0.001) were associated with higher IBD-DI scores. IBD-DI scores correlated with measures of disease activity, PM (r = 0.64, p < 0.001) and HBI (r = 0.65, p < 0.001). Patients with paediatric onset disease demonstrated significantly higher negative influencer scores (family, p = 0.04) and lower positive influencer scores (family, p = 0.02 and health professionals, p = 0.03.) Patients with paediatric onset IBD have a similar burden of disability compared with those with adult onset disease. They however were less likely to view family and health professional’s as facilitators and more likely to view family as a barrier to their disease and disability. Factors associated with higher disability scores include age>25 years, female gender, active smokers and clinically active disease. Reference 1. Gower-Rousseau C, Sarter H, Savoye G, et al. Validation of the inflammatory bowel disease disability index in a population-based cohort. Gut, 2017;66:588–596.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.003 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.002 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.019 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".