Cardiac β<sub>3</sub>‐adrenoceptors—A role in human pathophysiology?
Why is this work in the frame?
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
No Canadian affiliation. An affiliation-only frame — the usual design — would never have seen this work. It is one of the works that make the case for inverting the frame.
The three-model screen
all 1,000 screened works →All three models called this out of scope.
Pharmacology review of cardiac beta3-adrenoceptors in human pathophysiology.
It reviews cardiac receptor physiology and pharmacology, not research practice.
Pathophysiology review of cardiac β3-adrenoceptors; clinical/basic cardiology.
Abstract
As β 3 ‐adrenoceptors were first demonstrated to be expressed in adipose tissue they have received much attention for their metabolic effects in obesity and diabetes. After the existence of this subtype had been suggested to be present in the heart, studies focused on its role in cardiac function. While the presence and functional role of β 3 ‐adrenoceptors in the heart has not uniformly been detected, there is a broad consensus that they become up‐regulated in pathological conditions associated with increased sympathetic activity such as heart failure and diabetes. When detected, the β 3 ‐adrenceptor has been demonstrated to mediate negative inotropic effects in an inhibitory G protein‐dependent manner through the NO–cGMP–PKG signalling pathway. Whether these negative inotropic effects provide protection from the adverse effects induced by overstimulation of β 1 /β 2 ‐adrenoceptors or in themselves are potentially harmful is controversial, but ongoing clinical studies in patients with congestive heart failure are testing the hypothesis that β 3 ‐adrenceptor agonism has a beneficial effect. Linked Articles This article is part of a themed section on Adrenoceptors—New Roles for Old Players. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v176.14/issuetoc
Stored with the screening record, where it is evidence for the labels above.
The record
- Venue
- British Journal of Pharmacology
- Topic
- Receptor Mechanisms and Signaling
- Field
- Biochemistry, Genetics and Molecular Biology
- Canadian institutions
- —
- Funders
- Astellas Pharma CanadaDeutsche ForschungsgemeinschaftAnkara Universitesi
- Keywords
- InotropeHeart failurePathophysiologyDiabetes mellitusInternal medicineMedicineEndocrinologyAgonismPathologicalAdrenergic receptorBioinformaticsCardiologyBiologyReceptor
- Has abstract in OpenAlex
- yes