MétaCan
Menu
Back to cohort
Record W2917263971 · doi:10.1038/s41588-018-0342-2

Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations

2019· article· en· W2917263971 on OpenAlexaff
Phuwanat Sakornsakolpat, Dmitry Prokopenko, Maxime Lamontagne, Nicola Reeve, Anna L. Guyatt, Victoria E. Jackson, Nick Shrine, Dandi Qiao, Traci M. Bartz, Deog Kyeom Kim, Mi Kyeong Lee, Jeanne C. Latourelle, Xingnan Li, Jarrett D. Morrow, Ma’en Obeidat, Annah B. Wyss, Per Bakke, R. Graham Barr, Terri H. Beaty, Steven A. Belinsky, Guy Brusselle, James D. Crapo, Kim de Jong, Dawn L. DeMeo, Tasha E. Fingerlin, Sina A. Gharib, Amund Gulsvik, Ian P. Hall, John E. Hokanson, Woo Jin Kim, David A. Lomas, Stephanie J. London, Deborah A. Meyers, George O'connor, Stephen I. Rennard, David A. Schwartz, Paweł Śliwiński, David Sparrow, Ruth Tal‐Singer, Yohannes Tesfaigzi, Jørgen Vestbo, Judith M. Vonk, Jae‐Joon Yim, Xiaobo Zhou, Ani Manichaikul, Lies Lahousse, Edwin K. Silverman, H. Marike Boezen, Martin D. Tobin, Brian D. Hobbs, Michael H. Cho, Chiara Batini, Jing Hua Zhao, Matthias Wielscher, Stefan Weiß, Katherine A. Kentistou, James P. Cook, Jennie Hui, Stefan Karrasch, Medea Imboden, Sarah E. Harris, Jonathan Marten, Stefan Enroth, Shona M. Kerr, Ida Surakka, Véronique Vitart, Terho Lehtimäki, Ralf Ewert, Christian Gieger, Georg Homuth, Peter K. Joshi, Claudia Langenberg, Lars Lind, Jian’an Luan, Anubha Mahajan, Alison D. Murray, David J. Porteous, Rajesh Rawal, Blair H. Smith, Paul R. H. J. Timmers, Olli Raitakari, Mika Kähönen, Ozren Polašek, Ulf Gyllensten, Igor Rudan, Ian J. Deary, Nicole Probst‐Hensch, Holger Schulz, James F. Wilson, Beate Stubbe, Eleftheria Zeggini, Marjo‐Riitta Järvelin, Caroline Hayward, Andrew P. Morris, Àlvar Agustí, Wayne H. Anderson, Nawar Diar Bakerly, Robert Bals, Kathleen C. Barnes, Eugene R. Bleecker, Russell P. Bowler, Christopher E. Brightling, Marleen de Bruijne, Peter J. Castaldi, Bartolomé R. Celli, Harvey O. Coxson, Ron Crystal, Pim de Jong, Asger Dirksen, Jennifer Dy, Marilyn Foreman, Judith García‐Aymerich, Pierre Alain Gevenois, Soumitra Ghosh, Hester A. Gietema, Nadia N. Hansel, Craig P. Hersh, Eric A. Hoffman, Noor Kalsheker, Hans‐Ulrich Kauczor, Tarja Laitinen, Diether Lambrechts, Sang‐Do Lee, Augusto A. Litonjua, Daan W. Loth, Sharon M. Lutz, David S. Lynch, William MacNee, Merry‐Lynn McDonald, John D. Newell, Børge G. Nordestgaard, Yeon‐Mok Oh, Peter D. Paré, Massimo Pistolesi, Dirkje S. Postma, Milo A. Puhan, Elizabeth A. Regan, Stephen S. Rich, Joon Beom Seo, A. D. Short, Berend C. Stoel, David P. Strachan, Nicola Sverzellati, Gerben ter Riet, Edwin J.R. van Beek, Bram van Ginneken, Claus Vogelmeier, Louise V. Wain, Adam Wanner, George R. Washko, Els Wauters, Emiel F.�M. Wouters, Robert P. Young, Loems Zeigler-Heitbrock

Bibliographic record

VenueNature Genetics · 2019
Typearticle
Languageen
FieldMedicine
TopicChronic Obstructive Pulmonary Disease (COPD) Research
Canadian institutionsUniversité LavalSt. Paul's HospitalUniversity of British ColumbiaInstitut universitaire de cardiologie et de pneumologie de Québec
FundersBiotechnology and Biological Sciences Research CouncilNational Heart, Lung, and Blood InstituteMedical Research CouncilNational Institute for Health and Care ResearchWellcome Trust
KeywordsBiologyPhenotypePulmonary diseaseGeneticsDiseaseGenetic heterogeneityEvolutionary biologyGeneInternal medicineMedicine

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.002
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.003
Threshold uncertainty score0.011

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.002
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0010.001
Science and technology studies0.0000.000
Scholarly communication0.0010.000
Open science0.0000.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0030.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.007
GPT teacher head0.264
Teacher spread0.256 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations423
Published2019
Admission routes1
Has abstractno

Explore more

Same venueNature GeneticsSame topicChronic Obstructive Pulmonary Disease (COPD) ResearchFrench-language works237,207