A171 GERD IS NOT ASSOCIATED WITH JACKHAMMER ESOPHAGUS
Bibliographic record
Abstract
Dysphagia and non-cardiac chest pain are common referrals for esophageal motility testing. Hypertensive esophageal peristalsis, previously classified as “nutcracker esophagus,” has been re-labelled as “jackhammer esophagus” by the Chicago Classification of esophageal motility disorders (CC v3.0). Although the pathophysiology of jackhammer esophagus (JE) has yet to be elucidated, gastroesophageal acid reflux (GERD) has been implicated as a possible causative factor, based on the higher than expected incidence of GERD on patients with JE that has been seen in previous studies (43 - 47%). The aim of this present study is to determine if GERD is associated with JE when compared to symptomatic controls with normal HRM. Consecutive symptomatic patients who were referred for esophageal high-resolution manometry (HRM) studies in Calgary, AB from Nov 2013 to Sept 2018 were retrospectively analyzed. Patients with a manometric diagnosis of Jackhammer esophagus by CC v3.0 (≥ 2 hypercontractile swallows with distal contractile integral [DCI] > 8000 mmHg-s-cm) who also underwent ambulatory pH studies were compared to patients with normal HRM (controls). Groups were compared with Pearson’s chi-square testing and ANOVA as appropriate. This study was IRB approved. 20 JE patients and 82 controls who underwent both HRM and ambulatory pH testing were identified. Age and gender breakdown were similar between both groups (see Table 1). The most common presenting complaint in the JE group was dysphagia (35.0%) and in controls was heartburn (26.8%). Similar numbers of both groups were on PPI (50.0% JE, 51.2% controls). 3 (25.0%) JE patients and 14 (17.1%) controls had evidence of abnormal acid exposure on 24h ambulatory pH study (defined as DeMeester score > 14.7); this difference was not significant (p = 0.56). When abnormal acid exposure was defined as acid exposure time (AET) > 4.2%, there was no significant difference seen between both groups (p = 0.50). There were no significant differences seen between other parameters of the DeMeester score (see Table 1). Abnormal acid exposure on ambulatory pH study does not appear to be associated with JE, when compared to patients with normal HRM. This finding suggests that abnormal esophageal acid exposure is unlikely to be a causative factor for the peristaltic abnormalities seen in Jackhammer esophagus. Table 1: Demographics and GERD parameters None
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.004 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".